Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021
Abstrak
Summary Background Diabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), we produced location-specific, age-specific, and sex-specific estimates of diabetes prevalence and burden from 1990 to 2021, the proportion of type 1 and type 2 diabetes in 2021, the proportion of the type 2 diabetes burden attributable to selected risk factors, and projections of diabetes prevalence through 2050. Methods Estimates of diabetes prevalence and burden were computed in 204 countries and territories, across 25 age groups, for males and females separately and combined; these estimates comprised lost years of healthy life, measured in disability-adjusted life-years (DALYs; defined as the sum of years of life lost [YLLs] and years lived with disability [YLDs]). We used the Cause of Death Ensemble model (CODEm) approach to estimate deaths due to diabetes, incorporating 25 666 location-years of data from vital registration and verbal autopsy reports in separate total (including both type 1 and type 2 diabetes) and type-specific models. Other forms of diabetes, including gestational and monogenic diabetes, were not explicitly modelled. Total and type 1 diabetes prevalence was estimated by use of a Bayesian meta-regression modelling tool, DisMod-MR 2.1, to analyse 1527 location-years of data from the scientific literature, survey microdata, and insurance claims; type 2 diabetes estimates were computed by subtracting type 1 diabetes from total estimates. Mortality and prevalence estimates, along with standard life expectancy and disability weights, were used to calculate YLLs, YLDs, and DALYs. When appropriate, we extrapolated estimates to a hypothetical population with a standardised age structure to allow comparison in populations with different age structures. We used the comparative risk assessment framework to estimate the risk-attributable type 2 diabetes burden for 16 risk factors falling under risk categories including environmental and occupational factors, tobacco use, high alcohol use, high body-mass index (BMI), dietary factors, and low physical activity. Using a regression framework, we forecast type 1 and type 2 diabetes prevalence through 2050 with Socio-demographic Index (SDI) and high BMI as predictors, respectively. Findings In 2021, there were 529 million (95% uncertainty interval [UI] 500–564) people living with diabetes worldwide, and the global age-standardised total diabetes prevalence was 6·1% (5·8–6·5). At the super-region level, the highest age-standardised rates were observed in north Africa and the Middle East (9·3% [8·7–9·9]) and, at the regional level, in Oceania (12·3% [11·5–13·0]). Nationally, Qatar had the world's highest age-specific prevalence of diabetes, at 76·1% (73·1–79·5) in individuals aged 75–79 years. Total diabetes prevalence—especially among older adults—primarily reflects type 2 diabetes, which in 2021 accounted for 96·0% (95·1–96·8) of diabetes cases and 95·4% (94·9–95·9) of diabetes DALYs worldwide. In 2021, 52·2% (25·5–71·8) of global type 2 diabetes DALYs were attributable to high BMI. The contribution of high BMI to type 2 diabetes DALYs rose by 24·3% (18·5–30·4) worldwide between 1990 and 2021. By 2050, more than 1·31 billion (1·22–1·39) people are projected to have diabetes, with expected age-standardised total diabetes prevalence rates greater than 10% in two super-regions: 16·8% (16·1–17·6) in north Africa and the Middle East and 11·3% (10·8–11·9) in Latin America and Caribbean. By 2050, 89 (43·6%) of 204 countries and territories will have an age-standardised rate greater than 10%. Interpretation Diabetes remains a substantial public health issue. Type 2 diabetes, which makes up the bulk of diabetes cases, is largely preventable and, in some cases, potentially reversible if identified and managed early in the disease course. However, all evidence indicates that diabetes prevalence is increasing worldwide, primarily due to a rise in obesity caused by multiple factors. Preventing and controlling type 2 diabetes remains an ongoing challenge. It is essential to better understand disparities in risk factor profiles and diabetes burden across populations, to inform strategies to successfully control diabetes risk factors within the context of multiple and complex drivers. Funding Bill & Melinda Gates Foundation.
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K. Ong
Lauryn K. Stafford
Susan A. Mclaughlin
E. Boyko
S. Vollset
Amanda E Smith
Bronte E Dalton
J. Duprey
Jessica A Cruz
Hailey Hagins
Paulina A Lindstedt
Amirali Aali
Yohannes Abate
Melsew Dagne Abate
M. Abbasian
Zeinab Abbasi-Kangevari
M. Abbasi-Kangevari
S. ElHafeez
Rami Abd-Rabu
Deldar Morad Abdulah
A. Abdullah
V. Abedi
H. Abidi
R. Aboagye
Hassan Abolhassani
Eman Abu-Gharbieh
A. Abu-Zaid
T. D. Adane
Denberu Eshetie Adane
Isaac Yeboah Addo
O. Adegboye
Victor Adekanmbi
Abiola Adepoju
Q. Adnani
R. Afolabi
G. Agarwal
Z. Aghdam
Marcela Agudelo-Botero
Constanza Elizabeth Aguilera Arriagada
Williams Agyemang-Duah
B. Ahinkorah
Danish Ahmad
Rizwan Ahmad
Sajjad Ahmad
Aaminah Ahmad
A. Ahmadi
K. Ahmadi
Ayman Ahmed
Ali Ahmed
L. Ahmed
Syed Anees Ahmed
Marjan Ajami
R. Akinyemi
H. A. Hamad
S. Hasan
T. AL-Ahdal
T. Alalwan
Z. Al-Aly
Mohammad T. Albataineh
J. Alcalde-Rabanal
Sharifullah Alemi
Hassam Ali
T. Alinia
S. Aljunid
Sami A. Almustanyir
R. Al-Raddadi
N. Alvis-Guzmán
Firehiwot Amare
E. Ameyaw
S. Amiri
G. Amusa
C. Andrei
R. Anjana
A. Ansar
Golnoosh Ansari
A. Ansari-Moghaddam
A. Anyasodor
J. Arabloo
A. Aravkin
D. Areda
H. Arifin
Mesay Arkew
B. Armocida
J. Ärnlöv
A. Artamonov
Judie Arulappan
R. T. Aruleba
Ashokan Arumugam
Z. Aryan
Mulu Tiruneh Asemu
M. Asghari-Jafarabadi
Elaheh Askari
Daniel Asmelash
T. Astell‐Burt
Mohammad Athar
S. Athari
M. Atout
L. Ávila-Burgos
A. Awaisu
S. Azadnajafabad
B. DarshanB
Hassan Babamohamadi
Muhammad Badar
A. Badawi
A. Badiye
N. Baghcheghi
N. Bagheri
S. Bagherieh
S. Bah
S. Bahadory
Ruhai Bai
A. Baig
Ovidiu Constantin Baltatu
H. Baradaran
M. Barchitta
Mainak Bardhan
N. Barengo
T. Bärnighausen
M. Barone
Francesco Barone-Adesi
Amadou Barrow
Hamideh Bashiri
A. Basiru
S. Basu
S. Basu
A. Batiha
K. Batra
Mulat Tirfie Bayih
N. Bayileyegn
A. Behnoush
A. Bekele
M. A. Belete
U. Belgaumi
L. Belo
D. Bennett
I. Benseñor
Kidanemaryam Berhe
Alemshet Yirga Berhie
S. Bhaskar
A. Bhat
Jasvinder Singh Bhatti
B. Bikbov
Faiq Bilal
B. S. Bintoro
Saeid Bitaraf
V. Bitra
V. Bjegović-Mikanović
V. Bodolica
A. Boloor
Michael Brauer
J. Brazo-Sayavera
H. Brenner
Z. Butt
D. Calina
L. A. Campos
Ismael Campos-Nonato
Yin Cao
Chao Cao
J. Car
M. Carvalho
C. Castañeda-Orjuela
F. Catalá-López
E. Cerin
J. Chadwick
E. Chandrasekar
Gashaw Sisay Chanie
J. Charan
Vijay Kumar Chattu
Kirti Chauhan
H. Cheema
E. Abebe
Simiao Chen
N. Cherbuin
Fatemeh Chichagi
S. Chidambaram
W. C. Cho
Sonali Gajanan Choudhari
Rajiv Chowdhury
Emon Kalyan Chowdhury
D. Chu
I. Chukwu
S. Chung
Kaleb Coberly
A. Columbus
D. Contreras
Ewerton Cousin
M. Criqui
N. Cruz-Martins
S. Cuschieri
Bashir Dabo
O. Dadras
X. Dai
A. Damasceno
R. Dandona
L. Dandona
Saswati Das
A. Dascălu
N. Dash
M. Dashti
C. Dávila-Cervantes
V. D. L. Cruz-Góngora
G. R. Debele
Kourosh Delpasand
Fitsum Wolde Demisse
G. Demissie
Xinlei Deng
E. Denova-Gutiérrez
S. Deo
Emina Dervišević
Hardik D. Desai
Aragaw Tesfaw Desale
A. Dessie
F. Desta
Syed Masudur Rahman Dewan
Sourav Dey
K. Dhama
M. Dhimal
N. Diao
Daniel Diaz
M. Dinu
Mengistie Diress
S. Djalalinia
L. Doan
Deepa Dongarwar
F. W. S. Figueiredo
B. Duncan
S. Dutta
A. Dziedzic
H. Edinur
Michael Ekholuenetale
T. Ekundayo
I. Elgendy
Muhammed Elhadi
W. El‐Huneidi
Omar Abdelsadek Abdou Elmeligy
Mohamed A. Elmonem
Destaw Endeshaw
Hawi Leul Esayas
Habitu Birhan Eshetu
Farshid Etaee
I. Fadhil
A. Fagbamigbe
A. Fahim
Shahab Falahi
M. Faris
Hossein Farrokhpour
F. Farzadfar
A. Fatehizadeh
G. Fazli
Xiaoqi Feng
T. Y. Ferede
F. Fischer
David Flood
A. Forouhari
Roham Foroumadi
M. F. Koudehi
A. Gaidhane
Santosh Gaihre
A. Gaipov
Yaseen Galali
B. Ganesan
M. García-Gordillo
R. Gautam
Mesfin Gebrehiwot
Kahsu Gebrekidan
T. G. Gebremeskel
Lemma Getacher
F. Ghadirian
S. Ghamari
M. Nour
Fariba Ghassemi
Mahaveer Golechha
Pouya Goleij
D. Golinelli
S. Gopalani
Habtamu Alganeh Guadie
Shiyang Guan
T. Gudayu
R. Guimarães
Rashid Abdi Guled
R. Gupta
Kartik Gupta
Veera Gupta
Vikrant Gupta
B. Gyawali
Rasool Haddadi
N. Hadi
T. Haile
Ramtin Hajibeygi
A. Haj-Mirzaian
R. Halwani
S. Hamidi
G. Hankey
M. A. Hannan
S. Haque
Hamid Harandi
N. I. Harlianto
S. M. M. Hasan
S. Hasan
H. Hasani
S. Hassanipour
Mohammed Bheser Hassen
Johannes Haubold
Khezar Hayat
G. Heidari
Mohammad Heidari
K. Hessami
Y. Hiraike
R. Holla
S. Hossain
Md Shakhaoat Hossain
Mohammad-Salar Hosseini
M. Hosseinzadeh
H. Hosseinzadeh
Junjie. Huang
M. N. Huda
Salman T. Hussain
H. Huynh
B. Hwang
S. E. Ibitoye
Nayu Ikeda
I. Ilic
M. Ilic
L. Inbaraj
Afrin Iqbal
S. Islam
R. Islam
N. Ismail
Hiroyasu Iso
G. Isola
Ramaiah Itumalla
M. Iwagami
C. C. Iwu
I. Iyamu
Assefa N. Iyasu
L. Jacob
A. Jafarzadeh
H. Jahrami
Rajesh Jain
C. Jaja
Zahra Jamalpoor
E. Jamshidi
Balamurugan Janakiraman
K. Jayanna
Sathish Kumar Jayapal
S. Jayaram
R. Jayawardena
R. Jebai
Wonjeong Jeong
Yinzi Jin
Mohammad Jokar
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Abel Joseph
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Navjot Kaur
Sina Kazemian
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Yousef S. Khader
H. Khajuria
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Moien A. B. Khan
Maseer Khan
A. Khan
S. Khanal
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A. Khater
Sorour Khateri
Fatemeh Khorashadizadeh
J. Khubchandani
Biruk Getahun Kibret
Min Seo Kim
R. Kimokoti
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M. Kivimäki
Ali-Asghar Kolahi
Somayeh Komaki
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Nikhil Kothari
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K. Krishan
Yuvaraj Krishnamoorthy
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M. Kuddus
Rakesh Kumar
Hriday Kumar
Satyajit Kundu
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Ambily Kuttikkattu
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T. T. Le
Shaun Wen Huey Lee
Mu-Ho Lee
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Sang-Woong Lee
S. Lee
Samson Mideksa Legesse
J. Lenzi
Yongze Li
Ming-Chieh Li
Stephen S. Lim
L. Lim
Xuefeng Liu
Chaojie Liu
Chun-Han Lo
G. Lopes
S. Lorkowski
R. Lozano
G. Lucchetti
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J. Miranda
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Kebede Haile Misgina
Manish Mishra
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Elias Mossialos
E. Mostafavi
U. Mueller
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Format Sitasi
Akses Cepat
- Tahun Terbit
- 2023
- Bahasa
- en
- Total Sitasi
- 2410×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1016/S0140-6736(23)01301-6
- Akses
- Open Access ✓