Semantic Scholar Open Access 2021 53 sitasi

The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis.

S. Satapathy Mark R. Wilson

Abstrak

Clusterin (CLU) was the first reported secreted mammalian chaperone and impacts on serious diseases associated with inappropriate extracellular protein aggregation. Many studies have described intracellular CLU in locations outside the secretory system and recent work has shown that CLU can be released into the cytosol during cell stress. In this article, we critically evaluate evidence relevant to the proposed origins of cellular CLU found outside the secretory system, and advance the hypothesis that the cytosolic release of CLU induced by stress serves to facilitate the trafficking of misfolded proteins to the proteasome and autophagy for degradation. We also propose future research directions that could help establish CLU as a unique chaperone performing critical and synergic roles in both intracellular and extracellular proteostasis.

Topik & Kata Kunci

Medicine

Penulis (2)

S. Satapathy

Mark R. Wilson

Format Sitasi

APA MLA BibTeX

Satapathy, S., Wilson, M.R. (2021). The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis.. https://doi.org/10.1016/j.tibs.2021.01.005

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Informasi Jurnal

Tahun Terbit: 2021
Bahasa: en
Total Sitasi: 53×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.tibs.2021.01.005
Akses: Open Access ✓