A single–cell type transcriptomics map of human tissues
Abstrak
Single-cell RNA analysis has been integrated with spatial protein profiling to create a single–cell type map of human tissues. Advances in molecular profiling have opened up the possibility to map the expression of genes in cells, tissues, and organs in the human body. Here, we combined single-cell transcriptomics analysis with spatial antibody-based protein profiling to create a high-resolution single–cell type map of human tissues. An open access atlas has been launched to allow researchers to explore the expression of human protein-coding genes in 192 individual cell type clusters. An expression specificity classification was performed to determine the number of genes elevated in each cell type, allowing comparisons with bulk transcriptomics data. The analysis highlights distinct expression clusters corresponding to cell types sharing similar functions, both within the same organs and between organs.
Topik & Kata Kunci
Penulis (25)
Max J. Karlsson
Cheng Zhang
Loren Méar
Wen Zhong
A. Digre
Borbala Katona
E. Sjöstedt
L. Butler
J. Odeberg
P. Dusart
F. Edfors
P. Oksvold
K. von Feilitzen
M. Zwahlen
M. Arif
O. Altay
Xiangyu Li
M. Ozcan
Adil Mardonoglu
Linn Fagerberg
J. Mulder
Yonglun Luo
F. Pontén
M. Uhlén
C. Lindskog
Akses Cepat
- Tahun Terbit
- 2021
- Bahasa
- en
- Total Sitasi
- 1344×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1126/sciadv.abh2169
- Akses
- Open Access ✓