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Semantic Scholar Open Access 2016 439 sitasi

Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders

F. Brozovich C. Nicholson Chantal V. Degen Yuan Z. Gao M. Aggarwal +1 lainnya
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Abstrak

The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportunities for the future development of new therapeutics to regulate vascular function.

Topik & Kata Kunci

Medicine Biology

Penulis (6)

F

F. Brozovich

C

C. Nicholson

C

Chantal V. Degen

Y

Yuan Z. Gao

M

M. Aggarwal

K

K. Morgan

Format Sitasi

APA MLA BibTeX
Brozovich, F., Nicholson, C., Degen, C.V., Gao, Y.Z., Aggarwal, M., Morgan, K. (2016). Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders. https://doi.org/10.1124/pr.115.010652

Akses Cepat

Lihat di Sumber doi.org/10.1124/pr.115.010652
Informasi Jurnal
Tahun Terbit
2016
Bahasa
en
Total Sitasi
439×
Sumber Database
Semantic Scholar
DOI
10.1124/pr.115.010652
Akses
Open Access ✓