Semantic Scholar Open Access 2016 637 sitasi

Engineering hybrid exosomes by membrane fusion with liposomes

Yuko T. Sato Kaori Umezaki S. Sawada S. Mukai Y. Sasaki +3 lainnya

Lihat Sumber DOI

Abstrak

Exosomes are a valuable biomaterial for the development of novel nanocarriers as functionally advanced drug delivery systems. To control and modify the performance of exosomal nanocarriers, we developed hybrid exosomes by fusing their membranes with liposomes using the freeze–thaw method. Exosomes embedded with a specific membrane protein isolated from genetically modified cells were fused with various liposomes, confirming that membrane engineering methods can be combined with genetic modification techniques. Cellular uptake studies performed using the hybrid exosomes revealed that the interactions between the developed exosomes and cells could be modified by changing the lipid composition or the properties of the exogenous lipids. These results suggest that the membrane-engineering approach reported here offers a new strategy for developing rationally designed exosomes as hybrid nanocarriers for use in advanced drug delivery systems.

Topik & Kata Kunci

Medicine Chemistry

Penulis (8)

Yuko T. Sato

Kaori Umezaki

S. Sawada

S. Mukai

Y. Sasaki

N. Harada

H. Shiku

K. Akiyoshi

Format Sitasi

APA MLA BibTeX

Sato, Y.T., Umezaki, K., Sawada, S., Mukai, S., Sasaki, Y., Harada, N. et al. (2016). Engineering hybrid exosomes by membrane fusion with liposomes. https://doi.org/10.1038/srep21933

Akses Cepat

Lihat di Sumber doi.org/10.1038/srep21933

Informasi Jurnal

Tahun Terbit: 2016
Bahasa: en
Total Sitasi: 637×
Sumber Database: Semantic Scholar
DOI: 10.1038/srep21933
Akses: Open Access ✓