Semantic Scholar Open Access 2018 18 sitasi

Neurotensin and Dynorphin Bi-Directionally Modulates CeA Inhibition of oval BNST Neurons in Male Mice

C. Normandeau Maria Luisa Torruella Suarez P. Sarret Zoe A. McElligott E. Dumont

Lihat Sumber DOI

Abstrak

Neuropeptides are often co-expressed in neurons but their neurophysiological effects are commonly studied individually. Multiple neuropeptides may therefore be simultaneously released to coordinate proper neural circuit function. Here, we triggered the release of endogenous neuropeptides in brain slices from male mice to better understand the modulation of central amygdala (CeA) inhibitory inputs onto oval (ov) BNST neurons. We found that locally-released neurotensin (NT) and dynorphin (Dyn) antagonistically regulated CeA inhibitory inputs onto ovBNST neurons. NT and Dyn respectively increased and decreased CeA-to-ovBNST inhibitory inputs through NT receptor 1 (NTR1) and kappa opioid receptor (KOR). Additionally, NT and Dyn mRNAs were highly co-localized in ovBNST neurons suggesting that they may be released from the same cells. Together, we showed that NT and Dyn are key modulators of CeA inputs to ovBNST, paving the way to determine whether different conditions or states can alter the neuropeptidergic regulation of this particular brain circuit.

Topik & Kata Kunci

Chemistry Medicine Biology

Penulis (5)

C. Normandeau

Maria Luisa Torruella Suarez

P. Sarret

Zoe A. McElligott

E. Dumont

Format Sitasi

APA MLA BibTeX

Normandeau, C., Suarez, M.L.T., Sarret, P., McElligott, Z.A., Dumont, E. (2018). Neurotensin and Dynorphin Bi-Directionally Modulates CeA Inhibition of oval BNST Neurons in Male Mice. https://doi.org/10.1016/j.neuropharm.2018.09.031

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.neuropharm.2018.09.031

Informasi Jurnal

Tahun Terbit: 2018
Bahasa: en
Total Sitasi: 18×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.neuropharm.2018.09.031
Akses: Open Access ✓