Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma
Abstrak
Key Points Question Does treatment with neoadjuvant chemoradiotherapy plus surgery improve the long-term survival of patients with locally advanced esophageal squamous cell carcinoma (ESCC) compared with surgery alone? Findings In this randomized clinical trial of 451 patients with locally advanced ESCC, treatment with neoadjuvant chemoradiotherapy plus surgery showed significantly improved 5-year overall survival of 59.9% compared with 49.1% for surgery alone, as well as improved disease-free survival. Meaning In this study, long-term outcomes demonstrated a survival benefit from neoadjuvant chemoradiotherapy followed by surgery compared with surgery alone for the treatment of patients with locally advanced ESCC, indicating that this combination may be considered a standard of care in this patient population.
Topik & Kata Kunci
Penulis (26)
Han Yang
Hui Liu
Yu-ping Chen
Chengchu Zhu
W. Fang
Zhentao Yu
W. Mao
J. Xiang
Yongtao Han
Zhijian Chen
Haihua Yang
Jia-ming Wang
Q. Pang
Xiao Zheng
Huan-jun Yang
Tao Li
Xu Zhang
Qun Li
Gen-jie Wang
Baofu Chen
T. Mao
M. Kong
Xufeng Guo
Ting Lin
Mengzhong Liu
J. Fu
Akses Cepat
- Tahun Terbit
- 2021
- Bahasa
- en
- Total Sitasi
- 235×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1001/jamasurg.2021.2373
- Akses
- Open Access ✓