Semantic Scholar Open Access 2022 98 sitasi

Anatomy of four human Argonaute proteins

K. Nakanishi

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Abstrak

Abstract MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene expression post-transcriptionally. These non-coding regulatory RNAs become functional after loading into Argonaute (AGO) proteins to form the effector complexes. Humans have four AGO proteins, AGO1, AGO2, AGO3 and AGO4, which share a high sequence identity. Since most miRNAs are found across the four AGOs, it has been thought that they work redundantly, and AGO2 has been heavily studied as the exemplified human paralog. Nevertheless, an increasing number of studies have found that the other paralogs play unique roles in various biological processes and diseases. In the last decade, the structural study of the four AGOs has provided the field with solid structural bases. This review exploits the completed structural catalog to describe common features and differences in target specificity across the four AGOs.

Topik & Kata Kunci

Medicine

Penulis (1)

K. Nakanishi

Format Sitasi

APA MLA BibTeX

Nakanishi, K. (2022). Anatomy of four human Argonaute proteins. https://doi.org/10.1093/nar/gkac519

Akses Cepat

Lihat di Sumber doi.org/10.1093/nar/gkac519

Informasi Jurnal

Tahun Terbit: 2022
Bahasa: en
Total Sitasi: 98×
Sumber Database: Semantic Scholar
DOI: 10.1093/nar/gkac519
Akses: Open Access ✓