Semantic Scholar Open Access 2019 102 sitasi

A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity.

J. Bradfield S. Vogelezang J. Felix A. Chesi Ø. Helgeland +119 lainnya

Lihat Sumber DOI

Abstrak

Although hundreds of GWAS-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity, and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of thirty studies consisting of up to 13,005 cases (≥95th percentile of BMI achieved 2-18 years old) and 15,599 controls (consistently <50th percentile of BMI) of European, African, North/South American and East Asian ancestry. Suggestive loci were taken forward for replication in a sample of 1,888 cases and 4,689 controls from seven cohorts of European and North/South American ancestry. In addition to observing eighteen previously implicated BMI or obesity loci, for both early and late onset, we uncovered one completely novel locus in this trans-ancestral analysis (nearest gene: METTL15). The variant was nominally associated in only the European subgroup analysis but had a consistent direction of effect in other ethnicities. We then utilized trans-ancestral Bayesian analysis to narrow down the location of the probable causal variant at each genome-wide significant signal. Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to fewer than ten SNPs (FAIM2, GNPDA2, MC4R and SEC16B loci). In conclusion, an ethnically diverse setting has enabled us to both identify an additional pediatric obesity locus and further fine-map existing loci.

Topik & Kata Kunci

Biology Medicine

Penulis (124)

J. Bradfield

S. Vogelezang

J. Felix

A. Chesi

Ø. Helgeland

M. Horikoshi

V. Karhunen

Estelle Lowry

D. Cousminer

T. Ahluwalia

E. Thiering

Eileen Tai Hui Boh

M. Zafarmand

N. Vilor-Tejedor

Carol A. Wang

R. Joro

Zhanghua Chen

W. Gauderman

N. Pitkänen

E. Parra

L. Fernández-Rhodes

A. Alyass

C. Monnereau

J. Curtin

C. Have

Shana E. McCormack

Mette Hollensted

Christine Frithioff-Bøjsøe

A. Valladares-Salgado

Jesús Peralta-Romero

Y. Teo

M. Standl

J. Leinonen

Jens-Christian Holm

Triinu Peters

J. Vioque

Martine Vrijheid

A. Simpson

A. Custovic

M. Vaudel

M. Canouil

V. Lindi

M. Atalay

M. Kähönen

O. Raitakari

Barbera D. C. Schaik

R. Berkowitz

S. Cole

V. S. Voruganti

Yujie Wang

H. Highland

A. Comuzzie

N. Butte

A. Justice

S. Gahagan

E. Blanco

T. Lehtimäki

T. Lakka

J. Hebebrand

A. Bonnefond

N. Grarup

P. Froguel

L. Lyytikäinen

M. Cruz

S. Kobes

R. Hanson

B. Zemel

A. Hinney

K. Teo

D. Meyre

K. North

F. Gilliland

H. Bisgaard

Mariona Bustamante

K. Bønnelykke

C. Pennell

F. Rivadeneira

A. Uitterlinden

L. Baier

T. Vrijkotte

Joachim Heinrich

T. I. Sørensen

S. Saw

O. Pedersen

T. Hansen

Johan G. Eriksson

E. Widén

M. I. McCarthy

P. R. Njølstad

C. Power

Elina Hyppönen

S. Sebert

Christopher D. Brown

M. Järvelin

N. Timpson

Stefan Johansson

H. Hakonarson

V. Jaddoe

Format Sitasi

APA MLA BibTeX

Bradfield, J., Vogelezang, S., Felix, J., Chesi, A., Helgeland, Ø., Helgeland, Ø. et al. (2019). A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity.. https://doi.org/10.1093/HMG/DDZ161

@article{bradfield2019, author = {J. Bradfield and S. Vogelezang and J. Felix and A. Chesi and Ø. Helgeland and Ø. Helgeland and M. Horikoshi and V. Karhunen and Estelle Lowry and D. Cousminer and D. Cousminer and T. Ahluwalia and T. Ahluwalia and E. Thiering and Eileen Tai Hui Boh and M. Zafarmand and N. Vilor-Tejedor and Carol A. Wang and R. Joro and Zhanghua Chen and W. Gauderman and N. Pitkänen and N. Pitkänen and E. Parra and L. Fernández-Rhodes and L. Fernández-Rhodes and A. Alyass and C. Monnereau and J. Curtin and C. Have and Shana E. McCormack and Shana E. McCormack and Mette Hollensted and Christine Frithioff-Bøjsøe and Christine Frithioff-Bøjsøe and A. Valladares-Salgado and Jesús Peralta-Romero and Y. Teo and M. Standl and J. Leinonen and Jens-Christian Holm and Jens-Christian Holm and Triinu Peters and J. Vioque and Martine Vrijheid and Martine Vrijheid and A. Simpson and A. Custovic and M. Vaudel and M. Canouil and V. Lindi and M. Atalay and M. Kähönen and O. Raitakari and O. Raitakari and Barbera D. C. Schaik and R. Berkowitz and S. Cole and V. S. Voruganti and Yujie Wang and H. Highland and A. Comuzzie and N. Butte and A. Justice and A. Justice and S. Gahagan and E. Blanco and T. Lehtimäki and T. Lakka and J. Hebebrand and A. Bonnefond and A. Bonnefond and N. Grarup and P. Froguel and P. Froguel and L. Lyytikäinen and M. Cruz and S. Kobes and R. Hanson and B. Zemel and B. Zemel and A. Hinney and K. Teo and D. Meyre and K. North and F. Gilliland and H. Bisgaard and Mariona Bustamante and Mariona Bustamante and K. Bønnelykke and C. Pennell and F. Rivadeneira and F. Rivadeneira and A. Uitterlinden and A. Uitterlinden and L. Baier and T. Vrijkotte and Joachim Heinrich and Joachim Heinrich and T. I. Sørensen and T. I. Sørensen and S. Saw and O. Pedersen and T. Hansen and Johan G. Eriksson and Johan G. Eriksson and E. Widén and M. I. McCarthy and M. I. McCarthy and P. R. Njølstad and P. R. Njølstad and C. Power and Elina Hyppönen and Elina Hyppönen and S. Sebert and S. Sebert and Christopher D. Brown and M. Järvelin and N. Timpson and Stefan Johansson and Stefan Johansson and H. Hakonarson and H. Hakonarson and V. Jaddoe}, title = {A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity.}, year = {2019}, journal = {Semantic Scholar}, doi = {10.1093/HMG/DDZ161}, url = {https://www.semanticscholar.org/paper/88d12632208465728df30428aa567fe0a7a26fed}, }

Akses Cepat

Lihat di Sumber doi.org/10.1093/HMG/DDZ161

Informasi Jurnal

Tahun Terbit: 2019
Bahasa: en
Total Sitasi: 102×
Sumber Database: Semantic Scholar
DOI: 10.1093/HMG/DDZ161
Akses: Open Access ✓