O5‐08‐04: A NEW OPEN‐SOURCE MODELING FRAMEWORK TO ASSESS COST EFFECTIVENESS OF EARLY INTERVENTION IN ALZHEIMER'S DISEASE

community over time. Methods: Health administrative data from Ontario, Canada was used to identify a cohort of 62,622 community-dwelling adults aged 65 years or older with dementia on April 1, 2007. Individuals were followed for seven years and matched 1:1 to persons without dementia (controls) based on age, sex and comorbidities in order to compare trends in use of health services by setting over time. Health services included: acute care hospitalizations (including those with discharge delay); nursing home placement; and emergency department, home care, and physician visits. Rates and trends in health system use were compared between persons with dementia, as they remained alive and in the community, and controls. Trajectories of health system use were displayed visually using Sankey plots. Results: After seven years, 49.0% of persons with dementia had spent time in a nursing home (6.8% controls) and 64.5% had died (30.0% controls). Overall, persons with dementia were more likely than controls to use health services; particularly home care (rate ratio (RR) 3.02, 95% confidence interval (CI) 2.93 to 3.11) and experience hospitalizations with discharge delay (RR 2.36, 95% CI (2.30 to 2.42)). As they remained in the community over time, persons with dementia used home care at an increasingly intensive rate (10.7% increase per year, p<0.001), but rates of acute care hospitalization remained stable (p1⁄40.38). Persons with dementia experienced more emergency department visits than controls (RR1⁄41.23, 95% CI (1.21 to 1.25)), however rates of increase over time were similar between the groups (p1⁄40.27). Conclusions: Our approach to examine trends in rates of health system use among persons with dementia as they remained in the community over time is of particular value to capacity planning initiatives; particularly enumerating the increased intensity of home care service use. O5-08-04 A NEW OPEN-SOURCE MODELING FRAMEWORK TO ASSESS COST EFFECTIVENESS OF EARLY INTERVENTION IN ALZHEIMER’S DISEASE Colin Green, Ron Handels, Anders Gustavsson, Anders Wimo, Anders Skoldunger, Bengt Winblad, Linus Jonsson, University of Exeter Medical School, University of Exeter, Exeter, United Kingdom; Maastricht University; Department of Psychiatry and Neuropsychology; Alzheimer Centre Limburg; School for Mental Health and Neurosciences, Maastricht, Netherlands; Karolinska Institutet, Department for Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Solna, Sweden; Karolinska Institutet, Department for Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Solna, Sweden; Quantify Research, Stockholm, Sweden; Karolinska Institutet, Theme Aging, Stockholm, Sweden; Karolinska Institutet, Department NVS, Center for Alzheimer Research, Division of Neurogeriatrics, Solna, Sweden; H. Lundbeck A/S, Copenhagen, Denmark. Contact e-mail: c.green@exeter. ac.uk