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Semantic Scholar Open Access 2022 131 sitasi

Metabolic Engineering: Methodologies and Applications.

M. Volk V. Tran Shih-I Tan Shekhar Mishra Z. Fatma +5 lainnya
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Abstrak

Metabolic engineering aims to improve the production of economically valuable molecules through the genetic manipulation of microbial metabolism. While the discipline is a little over 30 years old, advancements in metabolic engineering have given way to industrial-level molecule production benefitting multiple industries such as chemical, agriculture, food, pharmaceutical, and energy industries. This review describes the design, build, test, and learn steps necessary for leading a successful metabolic engineering campaign. Moreover, we highlight major applications of metabolic engineering, including synthesizing chemicals and fuels, broadening substrate utilization, and improving host robustness with a focus on specific case studies. Finally, we conclude with a discussion on perspectives and future challenges related to metabolic engineering.

Topik & Kata Kunci

Medicine

Penulis (10)

M

M. Volk

V

V. Tran

S

Shih-I Tan

S

Shekhar Mishra

Z

Z. Fatma

A

A. Boob

H

Hongxiang Li

P

P. Xue

T

Teresa A. Martin

H

Huimin Zhao

Format Sitasi

APA MLA BibTeX
Volk, M., Tran, V., Tan, S., Mishra, S., Fatma, Z., Boob, A. et al. (2022). Metabolic Engineering: Methodologies and Applications.. https://doi.org/10.1021/acs.chemrev.2c00403

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Lihat di Sumber doi.org/10.1021/acs.chemrev.2c00403
Informasi Jurnal
Tahun Terbit
2022
Bahasa
en
Total Sitasi
131×
Sumber Database
Semantic Scholar
DOI
10.1021/acs.chemrev.2c00403
Akses
Open Access ✓