Adaptation and possible ancient interspecies introgression in pigs identified by whole-genome sequencing
Abstrak
Domestic pigs have evolved genetic adaptations to their local environmental conditions, such as cold and hot climates. We sequenced the genomes of 69 pigs from 15 geographically divergent locations in China and detected 41 million variants, of which 21 million were absent from the dbSNP database. In a genome-wide scan, we identified a set of loci that likely have a role in regional adaptations to high- and low-latitude environments within China. Intriguingly, we found an exceptionally large (14-Mb) region with a low recombination rate on the X chromosome that appears to have two distinct haplotypes in the high- and low-latitude populations, possibly underlying their adaptation to cold and hot environments, respectively. Surprisingly, the adaptive sweep in the high-latitude regions has acted on DNA that might have been introgressed from an extinct Sus species. Our findings provide new insights into the evolutionary history of pigs and the role of introgression in adaptation.
Penulis (26)
H. Ai
X. Fang
Bin Yang
Zhiyong Huang
Hao Chen
Likai Mao
Feng Zhang
Lu Zhang
Leilei Cui
Weiming He
Jie Yang
Xiaoming Yao
Lisheng Zhou
Lijuan Han
Jing Li
Silong Sun
Xianhua Xie
Boxian Lai
Ying Su
Yao Lu
Hui Yang
Tao Huang
W. Deng
R. Nielsen
Jun Ren
Lusheng Huang
Akses Cepat
- Tahun Terbit
- 2015
- Bahasa
- en
- Total Sitasi
- 323×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1038/ng.3199
- Akses
- Open Access ✓