Semantic Scholar Open Access 2008 951 sitasi

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.

Li Yang Jianhua Huang X. Ren Agnieszka E. Gorska A. Chytil +6 lainnya

Lihat Sumber DOI

Abstrak

Aberrant TGFbeta signaling is common in human cancers and contributes to tumor metastasis. Here, we demonstrate that Gr-1+CD11b+ myeloid cells are recruited into mammary carcinomas with type II TGF beta receptor gene (Tgfbr2) deletion and directly promote tumor metastasis. Gr-1+CD11b+ cells infiltrate into the invasive front of tumor tissues and facilitate tumor cell invasion and metastasis through a process involving metalloproteinase activity. This infiltration of Gr-1+CD11b+ cells also results in increased abundance of TGF beta 1 in tumors with Tgfbr2 deletion. The recruitment of Gr-1+CD11b+ cells into tumors with Tgfbr2 deletion involves two chemokine receptor axes, the SDF-1/CXCR4 and CXCL5/CXCR2 axes. Together, these data indicate that Gr-1+CD11b+ cells contribute to TGFbeta-mediated metastasis through enhancing tumor cell invasion and metastasis.

Topik & Kata Kunci

Biology Medicine

Penulis (11)

Li Yang

Jianhua Huang

X. Ren

Agnieszka E. Gorska

A. Chytil

M. Aakre

D. Carbone

L. Matrisian

A. Richmond

P. Lin

H. Moses

Format Sitasi

APA MLA BibTeX

Yang, L., Huang, J., Ren, X., Gorska, A.E., Chytil, A., Aakre, M. et al. (2008). Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.. https://doi.org/10.1016/j.ccr.2007.12.004

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.ccr.2007.12.004

Informasi Jurnal

Tahun Terbit: 2008
Bahasa: en
Total Sitasi: 951×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.ccr.2007.12.004
Akses: Open Access ✓