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Semantic Scholar Open Access 2024 9801 sitasi

Accurate structure prediction of biomolecular interactions with AlphaFold 3

Josh Abramson Jonas Adler Jack Dunger Richard Evans Tim Green +43 lainnya
Lihat Sumber DOI

Abstrak

The introduction of AlphaFold 21 has spurred a revolution in modelling the structure of proteins and their interactions, enabling a huge range of applications in protein modelling and design2, 3, 4, 5–6. Here we describe our AlphaFold 3 model with a substantially updated diffusion-based architecture that is capable of predicting the joint structure of complexes including proteins, nucleic acids, small molecules, ions and modified residues. The new AlphaFold model demonstrates substantially improved accuracy over many previous specialized tools: far greater accuracy for protein–ligand interactions compared with state-of-the-art docking tools, much higher accuracy for protein–nucleic acid interactions compared with nucleic-acid-specific predictors and substantially higher antibody–antigen prediction accuracy compared with AlphaFold-Multimer v.2.37,8. Together, these results show that high-accuracy modelling across biomolecular space is possible within a single unified deep-learning framework. AlphaFold 3 has a substantially updated architecture that is capable of predicting the joint structure of complexes including proteins, nucleic acids, small molecules, ions and modified residues with greatly improved accuracy over many previous specialized tools.

Topik & Kata Kunci

Medicine

Penulis (48)

J

Josh Abramson

J

Jonas Adler

J

Jack Dunger

R

Richard Evans

T

Tim Green

A

A. Pritzel

O

Olaf Ronneberger

L

Lindsay Willmore

A

Andrew J Ballard

J

Joshua Bambrick

S

Sebastian Bodenstein

D

David A Evans

C

Chia-Chun Hung

M

Michael O’Neill

D

D. Reiman

K

Kathryn Tunyasuvunakool

Z

Zachary Wu

A

Akvile Zemgulyte

E

Eirini Arvaniti

C

Charles Beattie

O

Ottavia Bertolli

A

Alex Bridgland

A

Alexey Cherepanov

M

Miles Congreve

A

A. Cowen-Rivers

A

Andrew Cowie

M

Michael Figurnov

F

Fabian B Fuchs

H

Hannah Gladman

R

Rishub Jain

Y

Yousuf A. Khan

C

Caroline M R Low

K

Kuba Perlin

A

Anna Potapenko

P

Pascal Savy

S

Sukhdeep Singh

A

A. Stecula

A

Ashok Thillaisundaram

C

Catherine Tong

S

Sergei Yakneen

E

Ellen D. Zhong

M

Michal Zielinski

A

Augustin Žídek

V

V. Bapst

P

Pushmeet Kohli

M

Max Jaderberg

D

D. Hassabis

J

J. Jumper

Format Sitasi

APA MLA BibTeX
Abramson, J., Adler, J., Dunger, J., Evans, R., Green, T., Pritzel, A. et al. (2024). Accurate structure prediction of biomolecular interactions with AlphaFold 3. https://doi.org/10.1038/s41586-024-07487-w

Akses Cepat

Lihat di Sumber doi.org/10.1038/s41586-024-07487-w
Informasi Jurnal
Tahun Terbit
2024
Bahasa
en
Total Sitasi
9801×
Sumber Database
Semantic Scholar
DOI
10.1038/s41586-024-07487-w
Akses
Open Access ✓