Mesenchymal Stem Cells in Regenerative Medicine
Abstrak
The body continuously changes, and this is controlled primarily by genetic factors. The same genomic program that brings the fertilized egg through a series of multiplication and differentiation changes to bring about the birth of a complete, multi-tissued organism also controls the continuous changes through neonatal, juvenile, and teen sta g es, and all of adulthood. T en-, 30-, 50-, 70- and 90- year-olds exemplify this continuous genetic and distinctive process of change. Importantly, the later stage of this process, referred to as aging, is not a disease state, but rather part of this genomically controlled continuum. The central feature of change is that progenitor cells divide and their progeny differentiate in a sequence of site-specific changes to both expand the dimensions of tissues and replace cells that naturally expire. Every cell in the body has a lifespan measured in minutes, weeks, or, in some rare cases, years. With only a few exceptions, the end-stage differentiated cells die within a fixed timeframe. The progenitor cells for that expired cell must replace the expired cells; the rate of replacement controls whether the tissue will increase in size, be maintained, or experience atrophy as seen in old age.
Topik & Kata Kunci
Penulis (1)
A. Caplan
Akses Cepat
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- 2019
- Bahasa
- en
- Total Sitasi
- 220×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1016/B978-0-12-385942-6.00043-3
- Akses
- Open Access ✓