Semantic Scholar Open Access 2022 1 sitasi

Syntheses, Characterizations, and Inhibition Activities Against Coxsackievirus B3 of Iodobenzoic Hydrazide Functionalized Hexamolybdates

Long-Sheng Wang Chao Guo Danny Hu Yan-Xi Zhao Huihui Liu +5 lainnya

Lihat Sumber DOI

Abstrak

A class of iodobenzoyldiazenido-functionalized POMs (TBA)3 [Mo6O18(=N=NCOAr)] (Ar = Ph-o-I (1); Ph-m-I (2); Ph-p-I (3); Ph-3,4-I2 (4); Ph-2,3,5-I3 (5) (TBA = tetrabutylammonium) were prepared via the refluxing reaction of α-octamolybdates, DCC, and corresponding hydrazides in dry acetonitrile. Their structures were determined by Fourier-transform infrared spectroscopy, ultraviolet–visible spectra, X-ray photoelectron spectroscopy, hydrogen-1 nuclear magnetic resonance, and high-resolution mass spectrometry. Research on the biological activity of title compounds shows that L3, L5, 3, and 5 demonstrate potent inhibitory activity against coxsackievirus B3 and low in vitro cytotoxic activity against Hep-2 cell lines. The covalent linkage between the iodobenzoyldiazenido components and POMs can enhance the molecular inhibitory efficiency of iodobenzohydrazides.

Topik & Kata Kunci

Medicine

Penulis (10)

Long-Sheng Wang

Chao Guo

Danny Hu

Yan-Xi Zhao

Huihui Liu

Yujie Dong

Shang-Bin Sun

Xinglong Liu

K. Hu

Yaning Wei

Format Sitasi

APA MLA BibTeX

Wang, L., Guo, C., Hu, D., Zhao, Y., Liu, H., Dong, Y. et al. (2022). Syntheses, Characterizations, and Inhibition Activities Against Coxsackievirus B3 of Iodobenzoic Hydrazide Functionalized Hexamolybdates. https://doi.org/10.3389/fchem.2022.841151

Akses Cepat

Lihat di Sumber doi.org/10.3389/fchem.2022.841151

Informasi Jurnal

Tahun Terbit: 2022
Bahasa: en
Total Sitasi: 1×
Sumber Database: Semantic Scholar
DOI: 10.3389/fchem.2022.841151
Akses: Open Access ✓