Semantic Scholar Open Access 2014 476 sitasi

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model.

L. Oestereich Anja Lüdtke Stephanie Wurr Toni Rieger C. Muñoz-Fontela +1 lainnya

Lihat Sumber DOI

Abstrak

Outbreaks of Ebola hemorrhagic fever in sub-Saharan Africa are associated with case fatality rates of up to 90%. Currently, neither a vaccine nor an effective antiviral treatment is available for use in humans. Here, we evaluated the efficacy of the pyrazinecarboxamide derivative T-705 (favipiravir) against Zaire Ebola virus (EBOV) in vitro and in vivo. T-705 suppressed replication of Zaire EBOV in cell culture by 4log units with an IC90 of 110μM. Mice lacking the type I interferon receptor (IFNAR(-)(/)(-)) were used as in vivo model for Zaire EBOV-induced disease. Initiation of T-705 administration at day 6 post infection induced rapid virus clearance, reduced biochemical parameters of disease severity, and prevented a lethal outcome in 100% of the animals. The findings suggest that T-705 is a candidate for treatment of Ebola hemorrhagic fever.

Topik & Kata Kunci

Biology Medicine

Penulis (6)

L. Oestereich

Anja Lüdtke

Stephanie Wurr

Toni Rieger

C. Muñoz-Fontela

S. Günther

Format Sitasi

APA MLA BibTeX

Oestereich, L., Lüdtke, A., Wurr, S., Rieger, T., Muñoz-Fontela, C., Günther, S. (2014). Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model.. https://doi.org/10.1016/j.antiviral.2014.02.014

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.antiviral.2014.02.014

Informasi Jurnal

Tahun Terbit: 2014
Bahasa: en
Total Sitasi: 476×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.antiviral.2014.02.014
Akses: Open Access ✓