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Semantic Scholar Open Access 2007 75 sitasi

Regulation of Foxo‐1 and the angiopoietin‐2/Tie2 system by shear stress

S. Chlench N. Mecha Disassa M. Hohberg Christian J. Hoffmann Theresa Pohlkamp +6 lainnya
Lihat Sumber DOI

Abstrak

Transcription factor Foxo‐1 can be inactivated via Akt‐mediated phosphorylation. Since shear stress activates Akt, we determined whether Foxo‐1 and the Foxo‐1‐dependent, angiogenesis‐related Ang‐2/Tie2‐system are influenced by shear stress in endothelial cells. Expression of Foxo‐1 and its target genes p27Kip1 and Ang‐2 was decreased under shear stress (6 dyn/cm2, 24 h), nuclear exclusion of Foxo‐1 by phosphorylation increased. eNOS and Tie2 were upregulated. No effects on Ang‐1 expression were detected. In conclusion, Foxo‐1 and Ang‐2/Tie2 are part of the molecular response to shear stress, which may regulate angiogenesis.

Topik & Kata Kunci

Chemistry Medicine

Penulis (11)

S

S. Chlench

N

N. Mecha Disassa

M

M. Hohberg

C

Christian J. Hoffmann

T

Theresa Pohlkamp

G

Gabriele Beyer

M

M. Bongrazio

L

L. Da Silva-Azevedo

O

O. Baum

A

A. Pries

A

A. Zakrzewicz

Format Sitasi

APA MLA BibTeX
Chlench, S., Disassa, N.M., Hohberg, M., Hoffmann, C.J., Pohlkamp, T., Beyer, G. et al. (2007). Regulation of Foxo‐1 and the angiopoietin‐2/Tie2 system by shear stress. https://doi.org/10.1016/j.febslet.2007.01.028

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.febslet.2007.01.028
Informasi Jurnal
Tahun Terbit
2007
Bahasa
en
Total Sitasi
75×
Sumber Database
Semantic Scholar
DOI
10.1016/j.febslet.2007.01.028
Akses
Open Access ✓