Semantic Scholar Open Access 2017 121 sitasi

Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons.

C. Baimel B. Lau Min Qiao S. Borgland

Lihat Sumber DOI

Abstrak

Circuit-specific signaling of ventral tegmental area (VTA) dopamine neurons drives different aspects of motivated behavior, but the neuromodulatory control of these circuits is unclear. We tested the actions of co-expressed lateral hypothalamic peptides, orexin A (oxA) and dynorphin (dyn), on projection-target-defined dopamine neurons in mice. We determined that VTA dopamine neurons that project to the nucleus accumbens lateral shell (lAcbSh), medial shell (mAcbSh), and basolateral amygdala (BLA) are largely non-overlapping cell populations with different electrophysiological properties. Moreover, the neuromodulatory effects of oxA and dyn on these three projections differed. OxA selectively increased firing in lAcbSh- and mAcbSh-projecting dopamine neurons. Dyn decreased firing in the majority of mAcbSh- and BLA-projecting dopamine neurons but reduced firing only in a small fraction of those that project to the lAcbSh. In conclusion, the oxA-dyn input to the VTA may drive reward-seeking behavior by tuning dopaminergic output in a projection-target-dependent manner.

Topik & Kata Kunci

Chemistry Medicine

Penulis (4)

C. Baimel

B. Lau

Min Qiao

S. Borgland

Format Sitasi

APA MLA BibTeX

Baimel, C., Lau, B., Qiao, M., Borgland, S. (2017). Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons.. https://doi.org/10.1016/j.celrep.2017.01.030

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.celrep.2017.01.030

Informasi Jurnal

Tahun Terbit: 2017
Bahasa: en
Total Sitasi: 121×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.celrep.2017.01.030
Akses: Open Access ✓