Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Abstrak
Summary Background Health system planning requires careful assessment of chronic kidney disease (CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-existent in many countries. We estimated the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function, for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. We use the term CKD to refer to the morbidity and mortality that can be directly attributed to all stages of CKD, and we use the term impaired kidney function to refer to the additional risk of CKD from cardiovascular disease and gout. Methods The main data sources we used were published literature, vital registration systems, end-stage kidney disease registries, and household surveys. Estimates of CKD burden were produced using a Cause of Death Ensemble model and a Bayesian meta-regression analytical tool, and included incidence, prevalence, years lived with disability, mortality, years of life lost, and disability-adjusted life-years (DALYs). A comparative risk assessment approach was used to estimate the proportion of cardiovascular diseases and gout burden attributable to impaired kidney function. Findings Globally, in 2017, 1·2 million (95% uncertainty interval [UI] 1·2 to 1·3) people died from CKD. The global all-age mortality rate from CKD increased 41·5% (95% UI 35·2 to 46·5) between 1990 and 2017, although there was no significant change in the age-standardised mortality rate (2·8%, −1·5 to 6·3). In 2017, 697·5 million (95% UI 649·2 to 752·0) cases of all-stage CKD were recorded, for a global prevalence of 9·1% (8·5 to 9·8). The global all-age prevalence of CKD increased 29·3% (95% UI 26·4 to 32·6) since 1990, whereas the age-standardised prevalence remained stable (1·2%, −1·1 to 3·5). CKD resulted in 35·8 million (95% UI 33·7 to 38·0) DALYs in 2017, with diabetic nephropathy accounting for almost a third of DALYs. Most of the burden of CKD was concentrated in the three lowest quintiles of Socio-demographic Index (SDI). In several regions, particularly Oceania, sub-Saharan Africa, and Latin America, the burden of CKD was much higher than expected for the level of development, whereas the disease burden in western, eastern, and central sub-Saharan Africa, east Asia, south Asia, central and eastern Europe, Australasia, and western Europe was lower than expected. 1·4 million (95% UI 1·2 to 1·6) cardiovascular disease-related deaths and 25·3 million (22·2 to 28·9) cardiovascular disease DALYs were attributable to impaired kidney function. Interpretation Kidney disease has a major effect on global health, both as a direct cause of global morbidity and mortality and as an important risk factor for cardiovascular disease. CKD is largely preventable and treatable and deserves greater attention in global health policy decision making, particularly in locations with low and middle SDI. Funding Bill & Melinda Gates Foundation.
Topik & Kata Kunci
Penulis (224)
Boris Caroline A Andrew S Mari Amir Molla Oladimeji M Mo Bikbov Purcell Levey Smith Abdoli Abebe Adebayo Af
B. Bikbov
Caroline A. Purcell
A. Levey
Mari Smith
Amir Abdoli
Molla Abebe
O. Adebayo
M. Afarideh
Sachin Agarwal
Marcela Agudelo-Botero
E. Ahmadian
Z. Al-Aly
V. Alipour
A. Almasi-Hashiani
R. Al-Raddadi
N. Alvis-Guzmán
S. Amini
Tudorel Andrei
C. Andrei
Zewudu Andualem
Mina Anjomshoa
J. Arabloo
A. Ashagre
Daniel Asmelash
Z. Ataro
M. Atout
M. Ayanore
A. Badawi
A. Bakhtiari
S. Ballew
A. Balouchi
Maciej Banach
S. Barquera
Sanjay Basu
Mulat Tirfie Bayih
Neeraj Bedi
A. Bello
I. Benseñor
Ali Bijani
A. Boloor
A. Borzì
L. Cámera
J. Carrero
F. Carvalho
Franz Castro
F. Catalá-López
Alex R. Chang
K. Chin
S. Chung
Massimo Cirillo
Ewerton Cousin
L. Dandona
R. Dandona
A. Daryani
R. Das Gupta
F. M. Demeke
Gebre Teklemariam Demoz
Desilu Mahari Desta
H. Do
B. Duncan
A. Eftekhari
A. Esteghamati
S. S. Fatima
João Fernandes
E. Fernandes
F. Fischer
M. Freitas
M. Gad
Gebreamlak Gebremedhn Gebremeskel
B. M. Gebresillassie
Birhanu Geta
M. Ghafourifard
A. Ghajar
N. Ghith
P. Gill
I. Ginawi
R. Gupta
N. Hafezi-Nejad
A. Haj-Mirzaian
A. Haj-Mirzaian
Ninuk Hariyani
M. Hasan
Milad Hasankhani
A. Hasanzadeh
H. Y. Hassen
Simon Iain Hay
B. Heidari
C. Herteliu
C. L. Hoang
M. Hosseini
M. Hostiuc
S. Irvani
S. Islam
Nader Jafari Balalami
S. James
S. Jassal
V. Jha
J. Jonas
F. Joukar
J. Jozwiak
Alia Kabir
Amaha Kahsay
A. Kasaeian
T. Kassa
Hagazi Gebremedhin Kassaye
Yousef S. Khader
Rovshan Khalilov
E. Khan
M. S. Khan
Y. Khang
A. Kisa
C. Kovesdy
Barthelemy Kuate Defo
G. Kumar
A. Larsson
L. Lim
Alan D. Lopez
P. Lotufo
A. Majeed
R. Malekzadeh
Winfried März
Anthony Masaka
H. Meheretu
T. Miazgowski
Andreea Mirica
E. Mirrakhimov
P. Mithra
B. Moazen
D. K. Mohammad
R. Mohammadpourhodki
S. Mohammed
A. Mokdad
Linda Morales
Ilais Moreno Velásquez
Seyyed Meysam Mousavi
S. Mukhopadhyay
J. Nachega
Girish N. Nadkarni
J. R. Nansseu
G. Natarajan
Javad Nazari
B. Neal
R. Negoi
C. Nguyen
Rajan Nikbakhsh
J. Noubiap
C. Nowak
A. Olagunju
Alberto Ortiz
M. Owolabi
R. Palladino
M. Pathak
H. Poustchi
S. Prakash
N. Prasad
A. Rafiei
S. Raju
K. Ramezanzadeh
S. Rawaf
D. Rawaf
Lal B Rawal
R. Reiner
A. Rezapour
Daniel Ribeiro
L. Roever
D. Rothenbacher
G. M. Rwegerera
S. Saadatagah
Saeed Safari
B. Sahle
Hosni Salem
J. Sanabria
I. Santos
Arash Sarveazad
M. Sawhney
E. Schaeffner
M.I. Schmidt
A. Schutte
S. Sepanlou
M. Shaikh
Z. Sharafi
M. Sharif
Amrollah Sharifi
D. Silva
Jasvinder A. Singh
N. Singh
M. M. Sisay
A. Soheili
I. Sutradhar
B. Teklehaimanot
B. Tesfay
Getnet Teshome
J. Thakur
M. Tonelli
Khanh B. Tran
B. Tran
Candide Tran Ngoc
I. Ullah
Pascual Valdez
S. Varughese
Theo Vos
L. G. Vu
Yasir Waheed
A. Werdecker
H. F. Wolde
A. Wondmieneh
Sarah Wulf Hanson
Tomohide Yamada
Yigizie Yeshaw
N. Yonemoto
H. Yusefzadeh
Z. Zaidi
Leila Zaki
S. Zaman
N. Zamora
A. Zarghi
Kaleab Alemayehu Zewdie
J. Ärnlöv
J. Coresh
N. Perico
G. Remuzzi
C. Murray
Theo Vos
Format Sitasi
Akses Cepat
- Tahun Terbit
- 2020
- Bahasa
- en
- Total Sitasi
- 4044×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1016/S0140-6736(20)30045-3
- Akses
- Open Access ✓