Semantic Scholar Open Access 2018 287 sitasi

Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications

Sarah A. Stewart Juan Domínguez-Robles R. Donnelly E. Larrañeta

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Abstrak

The oral route is a popular and convenient means of drug delivery. However, despite its advantages, it also has challenges. Many drugs are not suitable for oral delivery due to: first pass metabolism; less than ideal properties; and side-effects of treatment. Additionally, oral delivery relies heavily on patient compliance. Implantable drug delivery devices are an alternative system that can achieve effective delivery with lower drug concentrations, and as a result, minimise side-effects whilst increasing patient compliance. This article gives an overview of classification of these drug delivery devices; the mechanism of drug release; the materials used for manufacture; the various methods of manufacture; and examples of clinical applications of implantable drug delivery devices.

Topik & Kata Kunci

Materials Science Medicine

Penulis (4)

Sarah A. Stewart

Juan Domínguez-Robles

R. Donnelly

E. Larrañeta

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APA MLA BibTeX

Stewart, S.A., Domínguez-Robles, J., Donnelly, R., Larrañeta, E. (2018). Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications. https://doi.org/10.3390/polym10121379

Akses Cepat

Lihat di Sumber doi.org/10.3390/polym10121379

Informasi Jurnal

Tahun Terbit: 2018
Bahasa: en
Total Sitasi: 287×
Sumber Database: Semantic Scholar
DOI: 10.3390/polym10121379
Akses: Open Access ✓