Semantic Scholar Open Access 2009 1156 sitasi

Enteric defensins are essential regulators of intestinal microbial ecology

N. Salzman Kuiechun Hung Dipica Haribhai Hiutung Chu J. Karlsson-Sjöberg +12 lainnya

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Abstrak

Antimicrobial peptides are important effectors of innate immunity throughout the plant and animal kingdoms. In the mammalian small intestine, Paneth cell α-defensins are antimicrobial peptides that contribute to host defense against enteric pathogens. To determine if α-defensins also govern intestinal microbial ecology, we analyzed the intestinal microbiota of mice expressing a human α-defensin gene (DEFA5) and in mice lacking an enzyme required for the processing of mouse α-defensins. In these complementary models, we detected significant α-defensin-dependent changes in microbiota composition, but not in total bacterial numbers. Furthermore, DEFA5-expressing mice had striking losses of segmented filamentous bacteria and fewer interleukin 17 (IL-17)-producing lamina propria T cells. Our data ascribe a new homeostatic role to α-defensins in regulating the makeup of the commensal microbiota.

Topik & Kata Kunci

Medicine Biology

Penulis (17)

N. Salzman

Kuiechun Hung

Dipica Haribhai

Hiutung Chu

J. Karlsson-Sjöberg

Elad Amir

Paul Teggatz

Melissa Barman

Michael A. Hayward

D. Eastwood

M. Stoel

Yanjiao Zhou

E. Sodergren

G. Weinstock

C. Bevins

C. Williams

N. Bos

Format Sitasi

APA MLA BibTeX

Salzman, N., Hung, K., Haribhai, D., Chu, H., Karlsson-Sjöberg, J., Amir, E. et al. (2009). Enteric defensins are essential regulators of intestinal microbial ecology. https://doi.org/10.1038/ni.1825

Akses Cepat

Lihat di Sumber doi.org/10.1038/ni.1825

Informasi Jurnal

Tahun Terbit: 2009
Bahasa: en
Total Sitasi: 1156×
Sumber Database: Semantic Scholar
DOI: 10.1038/ni.1825
Akses: Open Access ✓