Semantic Scholar Open Access 2020 630 sitasi

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

Tyler N. Starr Allison J. Greaney Amin Addetia William W. Hannon M. Choudhary +3 lainnya

Lihat Sumber DOI

Abstrak

Antibodies are becoming a frontline therapy for SARS-CoV-2, but the risk of viral evolutionary escape remains unclear. Here we map how all mutations to SARS-CoV-2’s receptor-binding domain (RBD) affect binding by the antibodies in Regeneron’s REGN-COV2 cocktail and Eli Lilly’s LY-CoV016. These complete maps uncover a single amino-acid mutation that fully escapes the REGN-COV2 cocktail, which consists of two antibodies targeting distinct structural epitopes. The maps also identify viral mutations that are selected in a persistently infected patient treated with REGN-COV2, as well as in lab viral escape selections. Finally, the maps reveal that mutations escaping each individual antibody are already present in circulating SARS-CoV-2 strains. Overall, these complete escape maps enable immediate interpretation of the consequences of mutations observed during viral surveillance.

Topik & Kata Kunci

Biology Medicine

Penulis (8)

Tyler N. Starr

Allison J. Greaney

Amin Addetia

William W. Hannon

M. Choudhary

A. Dingens

Jonathan Z. Li

J. Bloom

Format Sitasi

APA MLA BibTeX

Starr, T.N., Greaney, A.J., Addetia, A., Hannon, W.W., Choudhary, M., Dingens, A. et al. (2020). Prospective mapping of viral mutations that escape antibodies used to treat COVID-19. https://doi.org/10.1101/2020.11.30.405472

Akses Cepat

Lihat di Sumber doi.org/10.1101/2020.11.30.405472

Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 630×
Sumber Database: Semantic Scholar
DOI: 10.1101/2020.11.30.405472
Akses: Open Access ✓