The development of Chinese population genetics by Ruofu Du

As a scientist, Professor Ruofu Du enjoyed an outstanding reputation both at home and abroad. For more than half a century, he devoted himself to the advancement of Chinese national anthropology and human population genetics, always keeping pace with global development trends of human genetics. As one of the founders of population genetics in China, Prof. Du promoted the human genome diversity project of China, and established the Chinese National Immortalized Cell Bank in Beijing, which is the most diverse population cell bank in China (http://lac.genetics.ac. cn/zhysxbk/ShowClass.asp?ClassID=17). Prof. Du compiled several books during his research career which have been widely used in the study of the basic theories of Chinese population genetics research. In 2014 Prof. Du won the “Anthropology of Lifetime Achievement Award”, which is sponsored by the Anthropological Association of Shanghai, to recognize those scientists in the field of anthropology who have made a significant and outstanding contribution the anthropology, for his 60 years of research in this field. After receiving his PhD degree from the Soviet Union Lenin Glennon College, Du returned to China in 1958, when he was 28 years old. There undertook a project to assess the effect of ionizing radiation on mammals and human genetics. Based on the research results of a survey into a population who were exposed to radiation in China, he provided direct evidence about the influence on human genetics of ionizing radiation (Ruofu Du, 1964). Subsequently, the Health Department modified the permissible irradiation dose of exposure to professional radiation staff of our country according to Du’s proposal. Prof. Du realized the scarcity of research data on human genetics in our country during this survey, and resolved to try his best to contribute in this field. Remarkably, Prof. Du continued his research work during the 10 years Cultural Revolution even though most of scientific research was forced to stop at that time. Meanwhile, he translated and published three important guiding books, The Radiation Genetics and Breeding of Crop, Handbook of Mutation Breeding and Molecular Genetics during this period of unrest, with the cooperation of Mr. Jike Yang (杨纪珂). In 1978 China began to introduce social reform and opening-up policies, after leading an academic visit to Australia, Prof. Du realized that Chinese research work had lagged far behind their international counterparts. When someone asked him, “What are you going to do when you go back home?” He said: “I think human genetics is the most backward in the field of genetics in our country. There has been a great deal of research into animals and plants, however as for research into human genetics, there are 56 ethnic groups and many special populations in China, but there is few related research about that, it is pity that we leave such a wealth of population genetic resources alone”. Thus, Du first proposed to carry out the study of human population genetics in China. Just as he said, “research of human population genetics is the need of the society and sciences, and that is my persistent goal.” In 1979 Prof. Du and his human population genetics research group in Institute of Genetics, Chinese Academy of Sciences, which was established in Beijing, visited many remote regions all over the country and carried out a systematic investigation into the physical anthropology and cultural anthropology of the 56 ethnic groups in China, including extensive sampling and analysis on several indicators of human population genetics (Fig. 1). Summing up the investigation, Prof. Du compiled two books, Chinese Nations and Chinese National Population Genetics (Ruofu Du, 1994, 2004). Chinese Nations is not only widely used as a reference book in the National Committee at all levels of our country and autonomous region, but also for ethnology, anthropology and population genetics researchers. Chinese National Population Genetics has been widely used as an introduction into the theories of genetics. Prof. Du stressed that the aim of Chinese population genetics research is to study genetic structure, the similarities and differences, as well as changes among the population of all ethnic groups in