Semantic Scholar Open Access 2020 532 sitasi

Organ-on-a-chip: recent breakthroughs and future prospects

Qirui Wu Jinfeng Liu Xiaohong Wang Lingyan Feng Jinbo Wu +3 lainnya

Lihat Sumber DOI

Abstrak

The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip. Through a combination of cell biology, engineering, and biomaterial technology, the microenvironment of the chip simulates that of the organ in terms of tissue interfaces and mechanical stimulation. This reflects the structural and functional characteristics of human tissue and can predict response to an array of stimuli including drug responses and environmental effects. OOAC has broad applications in precision medicine and biological defense strategies. Here, we introduce the concepts of OOAC and review its application to the construction of physiological models, drug development, and toxicology from the perspective of different organs. We further discuss existing challenges and provide future perspectives for its application.

Topik & Kata Kunci

Medicine Computer Science

Penulis (8)

Qirui Wu

Jinfeng Liu

Xiaohong Wang

Lingyan Feng

Jinbo Wu

Xiaoli Zhu

W. Wen

Xiuqing Gong

Format Sitasi

APA MLA BibTeX

Wu, Q., Liu, J., Wang, X., Feng, L., Wu, J., Zhu, X. et al. (2020). Organ-on-a-chip: recent breakthroughs and future prospects. https://doi.org/10.1186/s12938-020-0752-0

Akses Cepat

Lihat di Sumber doi.org/10.1186/s12938-020-0752-0

Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 532×
Sumber Database: Semantic Scholar
DOI: 10.1186/s12938-020-0752-0
Akses: Open Access ✓