Semantic Scholar Open Access 2017 355 sitasi

Ivermectin – Old Drug, New Tricks?

R. Laing Victoria Gillan E. Devaney

Lihat Sumber DOI

Abstrak

Ivermectin is one of the most important drugs in veterinary and human medicine for the control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or Medicine, some 35 years after its remarkable discovery. Although best described for its activity on glutamate-gated chloride channels in parasitic nematodes, understanding of its mode of action remains incomplete. In the field of veterinary medicine, resistance to ivermectin is now widespread, but the mechanisms underlying resistance are unresolved. Here we discuss the history of this versatile drug and its use in global health. Based on recent studies in a variety of systems, we question whether ivermectin could have additional modes of action on parasitic nematodes.

Topik & Kata Kunci

Medicine Biology

Penulis (3)

R. Laing

Victoria Gillan

E. Devaney

Format Sitasi

APA MLA BibTeX

Laing, R., Gillan, V., Devaney, E. (2017). Ivermectin – Old Drug, New Tricks?. https://doi.org/10.1016/j.pt.2017.02.004

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.pt.2017.02.004

Informasi Jurnal

Tahun Terbit: 2017
Bahasa: en
Total Sitasi: 355×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.pt.2017.02.004
Akses: Open Access ✓