Historical evolution of spheroids and organoids, and possibilities of use in life sciences and medicine
Abstrak
An impressive percentage of biomedical advances were achieved through animal research and cell culture investigations. For drug testing and disease researches, both animal models and preclinical trials with cell cultures are extremely important, but present some limitations, such as ethical concern and inability of representing complex tissues and organs. 3D cell cultures arise providing a more realistic in vitro representation of tissues and organs. Environment and cell type in 3D cultures can represent in vivo conditions and thus provide accurate data on cell‐to‐cell interactions, and cultivation techniques are based on a scaffold, usually hydrogel or another polymeric material, or without scaffold, such as suspended microplates, magnetic levitation, and microplates for spheroids with ultra‐low fixation coating.
Topik & Kata Kunci
Penulis (4)
M. Sakalem
M. D. De Sibio
Felipe Allan Da Silva Da Costa
Miriane de Oliveira
Akses Cepat
- Tahun Terbit
- 2020
- Bahasa
- en
- Total Sitasi
- 74×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1002/biot.202000463
- Akses
- Open Access ✓