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Semantic Scholar Open Access 2019 33 sitasi

Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region.

R. Hung M. Spitz R. Houlston A. Schwartz J. Field +63 lainnya
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Abstrak

INTRODUCTION Inherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study on the largest, to date, set of European-descent never-smokers with lung cancer. METHODS We conducted a two-phase (discovery and replication) genome-wide association study in never-smokers of European descent. We further augmented the sample by performing a meta-analysis with never-smokers from the recent OncoArray study, which resulted in a total of 3636 cases and 6295 controls. We also compare our findings with those in smokers with lung cancer. RESULTS We detected three genome-wide statistically significant single nucleotide polymorphisms rs31490 (odds ratio [OR]: 0.769, 95% confidence interval [CI]: 0.722-0.820; p value 5.31 × 10-16), rs380286 (OR: 0.770, 95% CI: 0.723-0.820; p value 4.32 × 10-16), and rs4975616 (OR: 0.778, 95% CI: 0.730-0.829; p value 1.04 × 10-14). All three mapped to Chromosome 5 CLPTM1L-TERT region, previously shown to be associated with lung cancer risk in smokers and in never-smoker Asian women, and risk of other cancers including breast, ovarian, colorectal, and prostate. CONCLUSIONS We found that genetic susceptibility to lung cancer in never-smokers is associated to genetic variants with pan-cancer risk effects. The comparison with smokers shows that top variants previously shown to be associated with lung cancer risk only confer risk in the presence of tobacco exposure, underscoring the importance of gene-environment interactions in the etiology of this disease.

Topik & Kata Kunci

Medicine

Penulis (68)

R

R. Hung

M

M. Spitz

R

R. Houlston

A

A. Schwartz

J

J. Field

J

J. Ying

Y

Yafang Li

Y

Younghun Han

X

Xuemei Ji

W

W. Chen

X

Xifeng Wu

I

I. Gorlov

J

Jie Na

M

M. Andrade

G

Geoffrey Liu

Y

Y. Brhane

N

Nancy Diao

A

A. Wenzlaff

M

M. Davies

T

T. Liloglou

M

Maria N. Timofeeva

M

Maria N. Timofeeva

T

T. Muley

H

H. Rennert

W

W. Saliba

B

B. Ryan

E

E. Bowman

J

J. Barros-Dios

M

M. Pérez-Ríos

H

H. Morgenstern

S

S. Zienolddiny

V

V. Skaug

D

D. Ugolini

S

S. Bonassi

E

Erik H. F. M. Heijden

A

A. Tardón

S

S. Bojesen

M

M. Landi

M

M. Johansson

H

H. Bickeböller

S

S. Arnold

L

L. Marchand

O

O. Melander

A

A. Andrew

K

K. Grankvist

N

N. Caporaso

M

M. Teare

M

M. Schabath

M

M. Aldrich

L

L. Kiemeney

H

H. Wichmann

P

P. Lazarus

J

J. Mayordomo

M

M. Neri

A

A. Haugen

Z

Zuo‐Feng Zhang

A

A. Ruano-Raviña

H

H. Brenner

C

C. Harris

I

I. Orlow

G

G. Rennert

A

Angela Risch

A

Angela Risch

P

P. Brennan

D

D. Christiani

C

C. Amos

P

Ping Yang

O

O. Gorlova

Format Sitasi

APA MLA BibTeX
Hung, R., Spitz, M., Houlston, R., Schwartz, A., Field, J., Ying, J. et al. (2019). Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region.. https://doi.org/10.1016/j.jtho.2019.04.008

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.jtho.2019.04.008
Informasi Jurnal
Tahun Terbit
2019
Bahasa
en
Total Sitasi
33×
Sumber Database
Semantic Scholar
DOI
10.1016/j.jtho.2019.04.008
Akses
Open Access ✓