Emergence and interstate spread of highly pathogenic avian influenza A(H5N1) in dairy cattle
Abstrak
Highly pathogenic avian influenza (HPAI) viruses cross species barriers and have the potential to cause pandemics. In North America, HPAI A(H5N1) viruses related to the goose/Guangdong 2.3.4.4b hemagglutinin phylogenetic clade have infected wild birds, poultry, and mammals. Our genomic analysis and epidemiological investigation showed that a reassortment event in wild bird populations preceded a single wild bird-to-cattle transmission episode. The movement of asymptomatic cattle has likely played a role in the spread of HPAI within the United States dairy herd. Some molecular markers in virus populations were detected at low frequency that may lead to changes in transmission efficiency and phenotype after evolution in dairy cattle. Continued transmission of H5N1 HPAI within dairy cattle increases the risk for infection and subsequent spread of the virus to human populations.
Penulis (27)
Thao-Quyen Nguyen
Carl R. Hutter
Alexey Markin
Megan N. Thomas
Kristina Lantz
M. Killian
Garrett M. Janzen
Sriram Vijendran
Sanket Wagle
Blake Inderski
Drew R. Magstadt
Ganwu Li
D. Diel
Elisha A Frye
K. Dimitrov
A. Swinford
Alexis C. Thompson
Kevin R. Snevik
D. L. Suarez
E. Spackman
Steven M. Lakin
Sara C. Ahola
Kammy R. Johnson
A. Baker
S. Robbe-Austerman
Mia K. Torchetti
T. Anderson
Akses Cepat
- Tahun Terbit
- 2024
- Bahasa
- en
- Total Sitasi
- 163×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1101/2024.05.01.591751
- Akses
- Open Access ✓