Self-Boosting Catalytic Nanoreactor Integrated with Triggerable Crosslinking Membrane Networks for Initiation of Immunogenic Cell Death by Pyroptosis.
Abstrak
Synthetic polymer vesicles spur novel strategies for producing biologically intelligent nanodevices with precise and specific functions (e.g. nanoreactors). Engineering vesicular nanodevices with tunable permeability by a general platform without involving trade-offs between structural integrity, flexibility and functionality remains challenging. Here, we present a general strategy to construct responsive nanoreactors based on polyion complex vesicles by integrating stimuli-responsive linkers into crosslinking membrane network. The formulated ROS-responsive nanoreactor with self-boosting catalytic glucose oxidation could protect glucose oxidase (GOD) to maintain long-term activity to achieve cytocidal function by oxidative stress induction and glucose starvation, which is ascribed to stimuli-responsive vesicle expansion without fracture and size-selective cargo release behavior. The GOD-loaded therapeutic nanoreactor induced an immunostimulatory form of cell death by pyroptosis, which has the great potential to prime anti-tumor immune responses.
Penulis (3)
Junjie Li
Y. Anraku
Kazunori Kataoka
Akses Cepat
- Tahun Terbit
- 2020
- Bahasa
- en
- Total Sitasi
- 49×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1002/anie.202004180
- Akses
- Open Access ✓