Semantic Scholar Open Access 2020 302 sitasi

SOX2 in development and cancer biology.

Daniel Novák Laura Hüser J. Elton V. Umansky P. Altevogt +1 lainnya

Lihat Sumber DOI

Abstrak

The transcription factor SOX2 is essential for embryonic development and plays a crucial role in maintaining the stemness of embryonic cells and various adult stem cell populations. On the other hand, dysregulation of SOX2 expression is associated with a multitude of cancer types and it has been shown that SOX2 positively affects cancer cell traits such as the capacity to proliferate, migrate, invade and metastasize. Moreover, there is growing evidence that SOX2 mediates resistance towards established cancer therapies and that it is expressed in cancer stem cells. These findings indicate that studying the role of SOX2 in the context of cancer progression could lead to the development of new therapeutic options. In this review, the current knowledge about the role of SOX2 in development, maintenance of stemness, cancer progression and the resistance towards cancer therapies is summarized.

Topik & Kata Kunci

Medicine Biology

Penulis (6)

Daniel Novák

Laura Hüser

J. Elton

V. Umansky

P. Altevogt

J. Utikal

Format Sitasi

APA MLA BibTeX

Novák, D., Hüser, L., Elton, J., Umansky, V., Altevogt, P., Utikal, J. (2020). SOX2 in development and cancer biology.. https://doi.org/10.1016/j.semcancer.2019.08.007

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.semcancer.2019.08.007

Informasi Jurnal

Tahun Terbit: 2020
Bahasa: en
Total Sitasi: 302×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.semcancer.2019.08.007
Akses: Open Access ✓