Semantic Scholar Open Access 2024 10 sitasi

COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants

P. Bay É. Audureau S. Preau R. Favory A. Guigon +86 lainnya

Lihat Sumber DOI

Abstrak

Background During the first COVID-19 pandemic wave, COVID-19-associated pulmonary aspergillosis (CAPA) has been reported in up to 11–28% of critically ill COVID-19 patients and associated with increased mortality. As new SARS-CoV-2 variants emerged, the characteristics of critically ill COVID-19 patients have evolved, particularly in the era of Omicron. The purpose of this study is to investigate the characteristics of CAPA in the era of new variants. Methods This is a prospective multicenter observational cohort study conducted in France in 36 participating intensive care units (ICU), between December 7th, 2021 and April 26th 2023. Diagnosis criteria of CAPA relied on European Confederation of Medical Mycology (ECMM)/International Society for Human & Animal Mycology (ISHAM) consensus criteria. Results 566 patients were included over the study period. The prevalence of CAPA was 5.1% [95% CI 3.4–7.3], and rose to 9.1% among patients who required invasive mechanical ventilation (IMV). Univariable analysis showed that CAPA patients were more frequently immunosuppressed and required more frequently IMV support, vasopressors and renal replacement therapy during ICU stay than non-CAPA patients. SAPS II score at ICU admission, immunosuppression, and a SARS-CoV-2 Delta variant were independently associated with CAPA in multivariable logistic regression analysis. Although CAPA was not significantly associated with day-28 mortality, patients with CAPA experienced a longer duration of mechanical ventilation and ICU stay. Conclusion This study contributes valuable insights into the prevalence, characteristics, and outcomes of CAPA in the era of Delta and Omicron variants. We report a lower prevalence of CAPA (5.1%) among critically-ill COVID-19 patients than previously reported, mainly affecting intubated-patients. Duration of mechanical ventilation and ICU stay were significantly longer in CAPA patients.

Topik & Kata Kunci

Medicine

Penulis (91)

P. Bay

É. Audureau

S. Preau

R. Favory

A. Guigon

N. Heming

E. Gault

Tài Pham

Amal Chaghouri

M. Turpin

L. Morand‐Joubert

S. Jochmans

A. Pitsch

Sylvie Meireles

D. Contou

Amandine Henry

Adrien Joseph

M. Chaix

F. Uhel

D. Roux

D. Descamps

M. Emery

Claudio Garcia-Sanchez

David Lévy

S. Burrel

J. Mayaux

A. Kimmoun

C. Hartard

F. Pène

Flore Rozenberg

S. Gaudry

Ségolène Brichler

Antoine Guillon

L. Handala

F. Tamion

A. Moisan

T. Daix

S. Hantz

F. Delamaire

V. Thibault

B. Souweine

Cécile Henquell

Lucile Picard

Françoise Botterel

C. Rodriguez

A. Mekontso Dessap

J. Pawlotsky

S. Fourati

N. de Prost

Keyvan Raphaël Elie Jean-François Guillaume Nina Stéphane Razazi Bellaïche Azoulay Timsit Voiriot de Montmol

K. Razazi

Raphaël Bellaïche

É. Azoulay

J. Timsit

G. Voiriot

Nina de Montmollin

S. Marot

Maxime Gasperment

T. Urbina

H. A. Oufella

Eric Maury Djeneba Bocar Fofana

C. Luyt

Djillali Annane

F. Meziani

L. Jandeaux

Samira Fafi-Kremer

C. Darreau

J. Thomin

A. Dartevel

S. Larrat

Evelyne Schvoerer

B. La Combe

Séverine Haouisee

Sami Hraeich

P. Fournier

Philippe Colson

E. Canet

B. Imbert

Guillaume Thiéry

Sylvie Pillet

R. Coudroy

Nicolas Lévêque

Clément Saccheri

Valerie Giordanengo

K. Klouche

E. Tuaillon

Cécile Aubron

Adissa Tran

J. Tadié

J. Plantier

S. Vallet

Format Sitasi

APA MLA BibTeX

Bay, P., Audureau, É., Preau, S., Favory, R., Guigon, A., Heming, N. et al. (2024). COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants. https://doi.org/10.1186/s13613-024-01296-0

@article{bay2024, author = {P. Bay and É. Audureau and S. Preau and R. Favory and A. Guigon and N. Heming and E. Gault and Tài Pham and Amal Chaghouri and M. Turpin and L. Morand‐Joubert and S. Jochmans and A. Pitsch and Sylvie Meireles and D. Contou and Amandine Henry and Adrien Joseph and M. Chaix and F. Uhel and D. Roux and D. Descamps and M. Emery and Claudio Garcia-Sanchez and David Lévy and S. Burrel and J. Mayaux and A. Kimmoun and C. Hartard and F. Pène and Flore Rozenberg and S. Gaudry and Ségolène Brichler and Antoine Guillon and L. Handala and F. Tamion and A. Moisan and T. Daix and S. Hantz and F. Delamaire and V. Thibault and B. Souweine and Cécile Henquell and Lucile Picard and Françoise Botterel and C. Rodriguez and A. Mekontso Dessap and J. Pawlotsky and S. Fourati and N. de Prost and Keyvan Raphaël Elie Jean-François Guillaume Nina Stéphane Razazi Bellaïche Azoulay Timsit Voiriot de Montmol and K. Razazi and Raphaël Bellaïche and É. Azoulay and J. Timsit and G. Voiriot and Nina de Montmollin and S. Marot and Maxime Gasperment and T. Urbina and H. A. Oufella and Eric Maury Djeneba Bocar Fofana and C. Luyt and Djillali Annane and F. Meziani and L. Jandeaux and Samira Fafi-Kremer and C. Darreau and J. Thomin and A. Dartevel and S. Larrat and Evelyne Schvoerer and B. La Combe and Séverine Haouisee and Sami Hraeich and P. Fournier and Philippe Colson and E. Canet and B. Imbert and Guillaume Thiéry and Sylvie Pillet and R. Coudroy and Nicolas Lévêque and Clément Saccheri and Valerie Giordanengo and K. Klouche and E. Tuaillon and Cécile Aubron and Adissa Tran and J. Tadié and J. Plantier and S. Vallet}, title = {COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants}, year = {2024}, journal = {Semantic Scholar}, doi = {10.1186/s13613-024-01296-0}, url = {https://www.semanticscholar.org/paper/4358384e2ef577f9ff5d970f61f42ce23b21e95d}, }

Akses Cepat

Lihat di Sumber doi.org/10.1186/s13613-024-01296-0

Informasi Jurnal

Tahun Terbit: 2024
Bahasa: en
Total Sitasi: 10×
Sumber Database: Semantic Scholar
DOI: 10.1186/s13613-024-01296-0
Akses: Open Access ✓