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Semantic Scholar Open Access 2021 22 sitasi

Cellular and molecular mechanisms regulating the KNDy neuronal activities to generate and modulate GnRH pulse in mammals.

Kana Ikegami Youki Watanabe Sho Nakamura Teppei Goto Naoko Inoue +2 lainnya
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Abstrak

Accumulating findings during the past decades have demonstrated that the hypothalamic arcuate kisspeptin neurons are supposed to be responsible for pulsatile release of gonadotropin-releasing hormone (GnRH) to regulate gametogenesis and steroidogenesis in mammals. The arcuate kisspeptin neurons express neurokinin B (NKB) and dynorphin A (Dyn), thus, the neurons are also referred to as KNDy neurons. In the present article, we mainly focus on the cellular and molecular mechanisms underlying GnRH pulse generation, that is focused on the action of NKB and Dyn and an interaction between KNDy neurons and astrocytes to control GnRH pulse generation. Then, we also discuss the factors that modulate the activity of KNDy neurons and consequent pulsatile GnRH/LH release in mammals.

Topik & Kata Kunci

Medicine

Penulis (7)

K

Kana Ikegami

Y

Youki Watanabe

S

Sho Nakamura

T

Teppei Goto

N

Naoko Inoue

Y

Y. Uenoyama

H

H. Tsukamura

Format Sitasi

APA MLA BibTeX
Ikegami, K., Watanabe, Y., Nakamura, S., Goto, T., Inoue, N., Uenoyama, Y. et al. (2021). Cellular and molecular mechanisms regulating the KNDy neuronal activities to generate and modulate GnRH pulse in mammals.. https://doi.org/10.1016/j.yfrne.2021.100968

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Lihat di Sumber doi.org/10.1016/j.yfrne.2021.100968
Informasi Jurnal
Tahun Terbit
2021
Bahasa
en
Total Sitasi
22×
Sumber Database
Semantic Scholar
DOI
10.1016/j.yfrne.2021.100968
Akses
Open Access ✓