Semantic Scholar Open Access 2007 786 sitasi

Properties, production, and applications of camelid single-domain antibody fragments

M. Harmsen H. de Haard

Lihat Sumber DOI

Abstrak

Camelids produce functional antibodies devoid of light chains of which the single N-terminal domain is fully capable of antigen binding. These single-domain antibody fragments (VHHs or Nanobodies®) have several advantages for biotechnological applications. They are well expressed in microorganisms and have a high stability and solubility. Furthermore, they are well suited for construction of larger molecules and selection systems such as phage, yeast, or ribosome display. This minireview offers an overview of (1) their properties as compared to conventional antibodies, (2) their production in microorganisms, with a focus on yeasts, and (3) their therapeutic applications.

Topik & Kata Kunci

Biology Medicine

Penulis (2)

M. Harmsen

H. de Haard

Format Sitasi

APA MLA BibTeX

Harmsen, M., Haard, H.d. (2007). Properties, production, and applications of camelid single-domain antibody fragments. https://doi.org/10.1007/s00253-007-1142-2

Akses Cepat

Lihat di Sumber doi.org/10.1007/s00253-007-1142-2

Informasi Jurnal

Tahun Terbit: 2007
Bahasa: en
Total Sitasi: 786×
Sumber Database: Semantic Scholar
DOI: 10.1007/s00253-007-1142-2
Akses: Open Access ✓