Semantic Scholar Open Access 2007 2140 sitasi

The mammalian epigenome.

B. Bernstein A. Meissner E. Lander

Lihat Sumber DOI

Abstrak

Chemical modifications to DNA and histone proteins form a complex regulatory network that modulates chromatin structure and genome function. The epigenome refers to the complete description of these potentially heritable changes across the genome. The composition of the epigenome within a given cell is a function of genetic determinants, lineage, and environment. With the sequencing of the human genome completed, investigators now seek a comprehensive view of the epigenetic changes that determine how genetic information is made manifest across an incredibly varied background of developmental stages, tissue types, and disease states. Here we review current research efforts, with an emphasis on large-scale studies, emerging technologies, and challenges ahead.

Topik & Kata Kunci

Medicine Biology

Penulis (3)

B. Bernstein

A. Meissner

E. Lander

Format Sitasi

APA MLA BibTeX

Bernstein, B., Meissner, A., Lander, E. (2007). The mammalian epigenome.. https://doi.org/10.1016/J.CELL.2007.01.033

Akses Cepat

Lihat di Sumber doi.org/10.1016/J.CELL.2007.01.033

Informasi Jurnal

Tahun Terbit: 2007
Bahasa: en
Total Sitasi: 2140×
Sumber Database: Semantic Scholar
DOI: 10.1016/J.CELL.2007.01.033
Akses: Open Access ✓