Semantic Scholar Open Access 1996 331 sitasi

The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.

J. Riesgo-Escovar M. Jenni A. Fritz E. Hafen

Lihat Sumber DOI

Abstrak

We cloned and characterized the Drosophila homolog of mammalian Jun-N-terminal kinases (DJNK). We show that DJNK is encoded by basket (bsk). Like hemipterous (hep), which encodes the Drosophila JNK kinase, bsk is required in the embryo for dorsal closure, a process involving coordinate cell shape changes of ectodermal cells. Dorsal closure can also be blocked by dominant negative Drosophila cdc42, which has been shown to act upstream of JNKK in vertebrates. Therefore it appears that the JNK pathway is conserved and that it is involved in controlling cell morphogenesis in Drosophila. Although DJNK efficiently phosphorylates DJun in vitro, bsk function is not required for the specification of cell fate in the developing eye, a process that requires MAP kinase and DJun function.

Topik & Kata Kunci

Biology Medicine

Penulis (4)

J. Riesgo-Escovar

M. Jenni

A. Fritz

E. Hafen

Format Sitasi

APA MLA BibTeX

Riesgo-Escovar, J., Jenni, M., Fritz, A., Hafen, E. (1996). The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.. https://doi.org/10.1101/GAD.10.21.2759

Akses Cepat

Lihat di Sumber doi.org/10.1101/GAD.10.21.2759

Informasi Jurnal

Tahun Terbit: 1996
Bahasa: en
Total Sitasi: 331×
Sumber Database: Semantic Scholar
DOI: 10.1101/GAD.10.21.2759
Akses: Open Access ✓