Semantic Scholar Open Access 2014 342 sitasi

Interactive Association of Drugs Binding to Human Serum Albumin

Feng Yang Yao Zhang Hong Liang

Lihat Sumber DOI

Abstrak

Human serum albumin (HSA) is an abundant plasma protein, which attracts great interest in the pharmaceutical industry since it can bind a remarkable variety of drugs impacting their delivery and efficacy and ultimately altering the drug’s pharmacokinetic and pharmacodynamic properties. Additionally, HSA is widely used in clinical settings as a drug delivery system due to its potential for improving targeting while decreasing the side effects of drugs. It is thus of great importance from the viewpoint of pharmaceutical sciences to clarify the structure, function, and properties of HSA–drug complexes. This review will succinctly outline the properties of binding site of drugs in IIA subdomain within the structure of HSA. We will also give an overview on the binding characterization of interactive association of drugs to human serum albumin that may potentially lead to significant clinical applications.

Topik & Kata Kunci

Chemistry Medicine

Penulis (3)

Feng Yang

Yao Zhang

Hong Liang

Format Sitasi

APA MLA BibTeX

Yang, F., Zhang, Y., Liang, H. (2014). Interactive Association of Drugs Binding to Human Serum Albumin. https://doi.org/10.3390/ijms15033580

Akses Cepat

Lihat di Sumber doi.org/10.3390/ijms15033580

Informasi Jurnal

Tahun Terbit: 2014
Bahasa: en
Total Sitasi: 342×
Sumber Database: Semantic Scholar
DOI: 10.3390/ijms15033580
Akses: Open Access ✓