Semantic Scholar Open Access 2019 263 sitasi

Central nervous system regeneration is driven by microglia necroptosis and repopulation

Amy F Lloyd C. L. Davies Rebecca K. Holloway Y. Labrak Graeme Ireland +11 lainnya

Lihat Sumber DOI

Abstrak

Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration. Lloyd et al. find that regeneration of CNS myelin requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state, revealing new therapeutic targets for neurodegenerative disease.

Topik & Kata Kunci

Medicine

Penulis (16)

Amy F Lloyd

C. L. Davies

Rebecca K. Holloway

Y. Labrak

Graeme Ireland

Dario Carradori

A. Dillenburg

Eva Borger

D. Soong

Jill C. Richardson

T. Kuhlmann

Anna C. Williams

J. Pollard

A. des Rieux

Josef Priller

V. Miron

Format Sitasi

APA MLA BibTeX

Lloyd, A.F., Davies, C.L., Holloway, R.K., Labrak, Y., Ireland, G., Carradori, D. et al. (2019). Central nervous system regeneration is driven by microglia necroptosis and repopulation. https://doi.org/10.1038/s41593-019-0418-z

Akses Cepat

Lihat di Sumber doi.org/10.1038/s41593-019-0418-z

Informasi Jurnal

Tahun Terbit: 2019
Bahasa: en
Total Sitasi: 263×
Sumber Database: Semantic Scholar
DOI: 10.1038/s41593-019-0418-z
Akses: Open Access ✓