Semantic Scholar Open Access 2006 809 sitasi

The evolution of adaptive immune systems.

M. Cooper M. Alder

Lihat Sumber DOI

Abstrak

A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen receptor is the central feature of the adaptive immune system that evolved in our vertebrate ancestors. The survival advantage gained through adding this type of adaptive immune system to a pre-existing innate immune system led to the evolution of alternative ways for lymphocytes to generate diverse antigen receptors for use in recognizing and repelling pathogen invaders. All jawed vertebrates assemble their antigen-receptor genes through recombinatorial rearrangement of different immunoglobulin or T cell receptor gene segments. The surviving jawless vertebrates, lampreys and hagfish, instead solved the receptor diversification problem by the recombinatorial assembly of leucine-rich-repeat genetic modules to encode variable lymphocyte receptors. The convergent evolution of these remarkably different adaptive immune systems involved innovative genetic modification of innate-immune-system components.

Topik & Kata Kunci

Biology Medicine

Penulis (2)

M. Cooper

M. Alder

Format Sitasi

APA MLA BibTeX

Cooper, M., Alder, M. (2006). The evolution of adaptive immune systems.. https://doi.org/10.1016/J.CELL.2006.02.001

Akses Cepat

Lihat di Sumber doi.org/10.1016/J.CELL.2006.02.001

Informasi Jurnal

Tahun Terbit: 2006
Bahasa: en
Total Sitasi: 809×
Sumber Database: Semantic Scholar
DOI: 10.1016/J.CELL.2006.02.001
Akses: Open Access ✓