Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function
Abstrak
In cardiac tissue engineering approaches to treat myocardial infarction, cardiac cells are seeded within three-dimensional porous scaffolds to create functional cardiac patches. However, current cardiac patches do not allow for online monitoring and reporting of engineered-tissue performance, and do not interfere to deliver signals for patch activation or to enable its integration with the host. Here, we report an engineered cardiac patch that integrates cardiac cells with flexible, free-standing electronics and a 3D nanocomposite scaffold. The patch exhibited robust electronic properties, enabling the recording of cellular electrical activities and the on-demand provision of electrical stimulation for synchronizing cell contraction. We also show that electroactive polymers containing biological factors can be deposited on designated electrodes to release drugs in the patch microenvironment on-demand. We expect that the integration of complex electronics within cardiac patches will eventually provide therapeutic control and regulation of cardiac function.
Topik & Kata Kunci
Penulis (8)
R. Feiner
L. Engel
Sharon Fleischer
Maayan Malki
Idan Gal
Assaf Shapira
Y. Shacham-Diamand
Tal Dvir
Akses Cepat
- Tahun Terbit
- 2016
- Bahasa
- en
- Total Sitasi
- 404×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1038/nmat4590
- Akses
- Open Access ✓