The Expression Characteristics and Correlation Analysis of Bone Mineral Density and Bone Turnover Biomarkers in CKD Patients

Background: Chronic kidney disease–mineral and bone disorder(CKD-MBD) is a common complication of CKD. It will cause renal osteopathy and vascular calcification. Methods: The patients were divided into four groups: CKD1-2 stage, CKD3-5ND stage, CKD5D stage and calciphylaxis. We analyzed the differences and variation tendency among groups. Logistic regression analysis showed the protect and risk factors for osteoporosis. Finally, we drew the ROC curves to explore if the BTMs can predict the osteoporosis. Results: 326 CKD patients was included. With the progression of the CKD, bone mineral density (BMD) decreased and bone turnover biomarkers(BTMs) became disordered, calciphylaxis patients were more serious than general dialysis patients. Logistic regression analysis showed that male(OR=0.558;OR=0.554)and BMI(OR=0.890;OR=0.911) were the protect factors of both left total hip and lumbar bone loss. LogPTH(OR=5.140)was risk factor of left total hip bone loss. ALP(OR=1.008) was risk factor for lumbar bone loss. The AUC of PTH and ALP were the highest one in the ROC curve of left total hip and lumbar respectively. Conclusions: When the GFR decreased, BMD and BTMs became abnormal gradually. The BMD of calciphylaxis patients were lower than other patients. PTH and ALP were risk factors and best predictors for osteoporosis in CKD patients.