Semantic Scholar Open Access 2019 212 sitasi

Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis.

J. Phelan S. Lang Jaehoon Sim S. Berritt A. Peat +3 lainnya

Lihat Sumber DOI

Abstrak

DNA-encoded library (DEL) technology is a powerful tool commonly used by the pharmaceutical industry for the identification of compounds with affinity to biomolecular targets. Success in this endeavor lies in sampling diverse chemical libraries. However, current DELs tend to be deficient in C(sp3) carbon counts. We report unique solutions to the challenge of increasing both the chemical diversity of these libraries and their C(sp3) carbon counts by merging Ni/photoredox dual catalytic C(sp2)-C(sp3) cross-coupling as well as photoredox-catalyzed radical/polar crossover alkylation protocols with DELs. The successful integration of multiple classes of radical sources enables the rapid incorporation of a diverse set of alkyl fragments.

Topik & Kata Kunci

Medicine Chemistry

Penulis (8)

J. Phelan

S. Lang

Jaehoon Sim

S. Berritt

A. Peat

Katelyn Billings

Lijun Fan

G. Molander

Format Sitasi

APA MLA BibTeX

Phelan, J., Lang, S., Sim, J., Berritt, S., Peat, A., Billings, K. et al. (2019). Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis.. https://doi.org/10.1021/jacs.9b00669

Akses Cepat

Lihat di Sumber doi.org/10.1021/jacs.9b00669

Informasi Jurnal

Tahun Terbit: 2019
Bahasa: en
Total Sitasi: 212×
Sumber Database: Semantic Scholar
DOI: 10.1021/jacs.9b00669
Akses: Open Access ✓