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Semantic Scholar Open Access 2026

Chemical constituents with cytotoxicity from the fresh roots of Rehmannia glutinosa (Gaertn.) Libosch. ex DC.

Fang-ge Chi Yan-gang Cao Hao-yu Wang Xu Chen Ze-Zhi Li +6 lainnya
Lihat Sumber DOI

Abstrak

Twenty-eight chemical constituents including seven previously undescribed compounds [1, 2, 10, (+)16, and 17-19] were isolated from the fresh roots of Rehmannia glutinosa (Gaertn.) Libosch. ex DC. Their structures were determined by NMR and MS datas, distinct J coupling constants, and quantum chemical calculations. All the isolated compounds were screened for their cytotoxicity against MCF-7 and Hep-G2 cell lines. The results indicated that compounds 1, 10, (+)16, and 18 showed potent cytotoxicity against MCF-7 cell lines, with IC50 values ranging from 17.2 ± 0.7 to 19.6 ± 0.7 μM, and compound 17 exhibited significant cytotoxicity against Hep-G2 cell lines, with IC50 value of 25.8 ± 1.2 μM.

Topik & Kata Kunci

Medicine

Penulis (11)

F

Fang-ge Chi

Y

Yan-gang Cao

H

Hao-yu Wang

X

Xu Chen

Z

Ze-Zhi Li

Y

Yanling Liu

D

Di Lu

Y

Ying Niu

B

Bing-xian Zhao

X

Xiao-ke Zheng

W

W. Feng

Format Sitasi

APA MLA BibTeX
Chi, F., Cao, Y., Wang, H., Chen, X., Li, Z., Liu, Y. et al. (2026). Chemical constituents with cytotoxicity from the fresh roots of Rehmannia glutinosa (Gaertn.) Libosch. ex DC.. https://doi.org/10.1016/j.fitote.2026.107180

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Lihat di Sumber doi.org/10.1016/j.fitote.2026.107180
Informasi Jurnal
Tahun Terbit
2026
Bahasa
en
Sumber Database
Semantic Scholar
DOI
10.1016/j.fitote.2026.107180
Akses
Open Access ✓