Semantic Scholar Open Access 2014 1596 sitasi

A comparative encyclopedia of DNA elements in the mouse genome

Feng Yue Yong Cheng A. Breschi J. Vierstra Weisheng Wu +129 lainnya

Lihat Sumber DOI

Abstrak

The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases.

Topik & Kata Kunci

Medicine Biology

Penulis (134)

Feng Yue

Yong Cheng

A. Breschi

J. Vierstra

Weisheng Wu

T. Ryba

R. Sandstrom

Zhihai Ma

Carrie A. Davis

Benjamin D. Pope

Yin Shen

D. Pervouchine

S. Djebali

B. Thurman

R. Kaul

Eric Rynes

Anthony Kirilusha

G. Marinov

B. Williams

Diane Trout

Henry Amrhein

Katherine I. Fisher-Aylor

I. Antoshechkin

Gilberto Desalvo

L. See

Meagan Fastuca

J. Drenkow

C. Zaleski

A. Dobin

Pablo Prieto

Julien Lagarde

G. Bussotti

Andrea Tanzer

Olgert Denas

Kanwei Li

M. Bender

Miaohua Zhang

Rachel Byron

M. Groudine

David F. McCleary

Long Pham

Z. Ye

Samantha Kuan

Lee E. Edsall

Yi-Chieh Wu

Matthew D. Rasmussen

M. Bansal

C. Keller

Christapher S. Morrissey

Tejaswini Mishra

D. Jain

Nergiz Dogan

Robert S. Harris

Philip Cayting

T. Kawli

A. Boyle

G. Euskirchen

Anshul B Kundaje

Shin Lin

Yiing Lin

C. Jansen

V. Malladi

M. Cline

Drew T. Erickson

V. Kirkup

K. Learned

C. A. Sloan

K. Rosenbloom

Beatriz de Sousa

Kathryn M Beal

M. Pignatelli

P. Flicek

Jin Lian

Tamer Kahveci

Dongwon Lee

W. Kent

Miguel Santos

Javier Herrero

Cédric Notredame

Audra K. Johnson

Shinny Vong

Kristen Lee

Daniel Bates

Fidencio V. Neri

Morgan Diegel

T. Canfield

P. Sabo

M. Wilken

T. Reh

Erika Giste

A. Shafer

T. Kutyavin

E. Haugen

D. Dunn

Alex P. Reynolds

Shane J. Neph

R. Humbert

R. Hansen

M. D. de Bruijn

L. Selleri

A. Rudensky

Steven Z. Josefowicz

R. Samstein

E. Eichler

S. Orkin

D. Levasseur

T. Papayannopoulou

Kai‐Hsin Chang

A. Skoultchi

S. Gosh

C. Disteche

P. Treuting

Yanli Wang

M. Weiss

G. Blobel

P. Good

Rebecca F. Lowdon

Leslie B. Adams

Xiao-qiao Zhou

M. Pazin

E. Feingold

B. Wold

James Taylor

Manolis Kellis

A. Mortazavi

S. Weissman

J. Stamatoyannopoulos

M. Snyder

R. Guigó

T. Gingeras

D. Gilbert

R. Hardison

Michael A. Beer

B. Ren

Format Sitasi

APA MLA BibTeX

Yue, F., Cheng, Y., Breschi, A., Vierstra, J., Wu, W., Ryba, T. et al. (2014). A comparative encyclopedia of DNA elements in the mouse genome. https://doi.org/10.1038/nature13992

@article{yue2014, author = {Feng Yue and Yong Cheng and A. Breschi and J. Vierstra and Weisheng Wu and T. Ryba and R. Sandstrom and Zhihai Ma and Carrie A. Davis and Benjamin D. Pope and Yin Shen and D. Pervouchine and S. Djebali and B. Thurman and R. Kaul and Eric Rynes and Anthony Kirilusha and G. Marinov and B. Williams and Diane Trout and Henry Amrhein and Katherine I. Fisher-Aylor and I. Antoshechkin and Gilberto Desalvo and L. See and Meagan Fastuca and J. Drenkow and C. Zaleski and A. Dobin and Pablo Prieto and Julien Lagarde and G. Bussotti and Andrea Tanzer and Olgert Denas and Kanwei Li and M. Bender and Miaohua Zhang and Rachel Byron and M. Groudine and David F. McCleary and Long Pham and Z. Ye and Samantha Kuan and Lee E. Edsall and Yi-Chieh Wu and Matthew D. Rasmussen and M. Bansal and C. Keller and Christapher S. Morrissey and Tejaswini Mishra and D. Jain and Nergiz Dogan and Robert S. Harris and Philip Cayting and T. Kawli and A. Boyle and G. Euskirchen and Anshul B Kundaje and Shin Lin and Yiing Lin and C. Jansen and V. Malladi and M. Cline and Drew T. Erickson and V. Kirkup and K. Learned and C. A. Sloan and K. Rosenbloom and Beatriz de Sousa and Kathryn M Beal and M. Pignatelli and P. Flicek and Jin Lian and Tamer Kahveci and Dongwon Lee and W. Kent and Miguel Santos and Javier Herrero and Cédric Notredame and Audra K. Johnson and Shinny Vong and Kristen Lee and Daniel Bates and Fidencio V. Neri and Morgan Diegel and T. Canfield and P. Sabo and M. Wilken and T. Reh and Erika Giste and A. Shafer and T. Kutyavin and E. Haugen and D. Dunn and Alex P. Reynolds and Shane J. Neph and R. Humbert and R. Hansen and M. D. de Bruijn and L. Selleri and A. Rudensky and Steven Z. Josefowicz and R. Samstein and E. Eichler and S. Orkin and D. Levasseur and T. Papayannopoulou and Kai‐Hsin Chang and A. Skoultchi and S. Gosh and C. Disteche and P. Treuting and Yanli Wang and M. Weiss and G. Blobel and P. Good and Rebecca F. Lowdon and Leslie B. Adams and Xiao-qiao Zhou and M. Pazin and E. Feingold and B. Wold and James Taylor and Manolis Kellis and A. Mortazavi and S. Weissman and J. Stamatoyannopoulos and M. Snyder and R. Guigó and T. Gingeras and D. Gilbert and R. Hardison and Michael A. Beer and B. Ren}, title = {A comparative encyclopedia of DNA elements in the mouse genome}, year = {2014}, journal = {Semantic Scholar}, doi = {10.1038/nature13992}, url = {https://www.semanticscholar.org/paper/277cdb73652a231fc914f6588be1c89921bccff0}, }

Akses Cepat

Lihat di Sumber doi.org/10.1038/nature13992

Informasi Jurnal

Tahun Terbit: 2014
Bahasa: en
Total Sitasi: 1596×
Sumber Database: Semantic Scholar
DOI: 10.1038/nature13992
Akses: Open Access ✓