Semantic Scholar Open Access 2022 2 sitasi

Clusterin is associated with Alzheimer’s disease biomarkers and cognitive scores in the pre‐symptomatic phase of the disease.

M. Dauar C. Picard P. Rosa-Neto S. Villeneuve J. Poirier

Abstrak

Clusterin (CLU) is one of the main genetic risk factors of late onset Alzheimer’s disease (AD), and different polymorphisms have been associated with the disease. A GWAS performed in a population isolate from eastern Canada has found the polymorphism rs11136000 of the CLU gene to be associated with increased risk for AD. For the present work, we used two different cohorts (the “at‐risk” pre‐symptomatic PREVENT‐AD and the symptomatic ROSMAP cohort) with the objective of exploring how the rs11136000 polymorphism is associated with clinical manifestations, biomarkers and neuropathology of AD at different disease stages.

Penulis (5)

M. Dauar

C. Picard

P. Rosa-Neto

S. Villeneuve

J. Poirier

Format Sitasi

APA MLA BibTeX

Dauar, M., Picard, C., Rosa-Neto, P., Villeneuve, S., Poirier, J. (2022). Clusterin is associated with Alzheimer’s disease biomarkers and cognitive scores in the pre‐symptomatic phase of the disease.. https://doi.org/10.1002/alz.062741

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Informasi Jurnal

Tahun Terbit: 2022
Bahasa: en
Total Sitasi: 2×
Sumber Database: Semantic Scholar
DOI: 10.1002/alz.062741
Akses: Open Access ✓