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Semantic Scholar Open Access 2019 274 sitasi

A review of the possible associations between ambient PM2.5 exposures and the development of Alzheimer's disease.

Yikai Shou Yilu Huang Xiaozheng Zhu Cuiqing Liu Yu Hu +1 lainnya
Lihat Sumber DOI

Abstrak

PM2.5 particles in air pollution have been widely considered associated with respiratory and cardiovascular diseases. Recent studies have shown that PM2.5 can also cause central nervous system (CNS) diseases, including a variety of neurodegenerative diseases, such as Alzheimer's disease (AD). Activation of microglia in the central nervous system can lead to inflammatory and neurological damage. PM2.5 will reduce the methylation level of DNA and affect epigenetics. PM2.5 enters the human body through a variety of pathways to have pathological effects on CNS. For example, PM2.5 can destroy the integrity of the blood-brain barrier (BBB), so peripheral systemic inflammation easily crosses BBB and reaches CNS. The olfactory nerve is another way for PM2.5 particles to enter the brain. Surprisingly, PM2.5 can also enter the gastrointestinal tract, causing imbalances in the intestinal microecology to affect central nervous system diseases. The current work collected and discuss the mechanisms of PM2.5-induced CNS damage and PM2.5-induced neurodegenerative diseases.

Topik & Kata Kunci

Medicine

Penulis (6)

Y

Yikai Shou

Y

Yilu Huang

X

Xiaozheng Zhu

C

Cuiqing Liu

Y

Yu Hu

H

Huanhuan Wang

Format Sitasi

APA MLA BibTeX
Shou, Y., Huang, Y., Zhu, X., Liu, C., Hu, Y., Wang, H. (2019). A review of the possible associations between ambient PM2.5 exposures and the development of Alzheimer's disease.. https://doi.org/10.1016/j.ecoenv.2019.02.086

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Informasi Jurnal
Tahun Terbit
2019
Bahasa
en
Total Sitasi
274×
Sumber Database
Semantic Scholar
DOI
10.1016/j.ecoenv.2019.02.086
Akses
Open Access ✓