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Semantic Scholar Open Access 2014 2134 sitasi

A draft map of the human proteome

Min-Sik Kim S. Pinto D. Getnet R. Nirujogi Srikanth S. Manda +67 lainnya
Lihat Sumber DOI

Abstrak

The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here we present a draft map of the human proteome using high-resolution Fourier-transform mass spectrometry. In-depth proteomic profiling of 30 histologically normal human samples, including 17 adult tissues, 7 fetal tissues and 6 purified primary haematopoietic cells, resulted in identification of proteins encoded by 17,294 genes accounting for approximately 84% of the total annotated protein-coding genes in humans. A unique and comprehensive strategy for proteogenomic analysis enabled us to discover a number of novel protein-coding regions, which includes translated pseudogenes, non-coding RNAs and upstream open reading frames. This large human proteome catalogue (available as an interactive web-based resource at http://www.humanproteomemap.org) will complement available human genome and transcriptome data to accelerate biomedical research in health and disease.

Topik & Kata Kunci

Biology Medicine

Penulis (72)

M

Min-Sik Kim

S

S. Pinto

D

D. Getnet

R

R. Nirujogi

S

Srikanth S. Manda

R

Raghothama Chaerkady

A

Anil K. Madugundu

D

Dhanashree S. Kelkar

R

Ruth Isserlin

S

Shobhit Jain

J

J. K. Thomas

B

B. Muthusamy

P

Pamela Leal-Rojas

P

Praveen Kumar

N

Nandini A. Sahasrabuddhe

L

Lavanya Balakrishnan

J

Jayshree Advani

B

B. George

S

S. Renuse

L

L. D. N. Selvan

A

Arun H. Patil

V

Vishalakshi Nanjappa

A

A. Radhakrishnan

S

Samarjeet Prasad

T

Tejaswini Subbannayya

R

Rajesh Raju

M

Manish Kumar

S

S. Sreenivasamurthy

A

Arivusudar Marimuthu

G

G. Sathe

S

S. Chavan

K

K. Datta

Y

Yashwanth Subbannayya

A

A. Sahu

S

S. Yelamanchi

S

Savita Jayaram

P

Pavithra Rajagopalan

J

Jyoti Sharma

K

K. Murthy

N

Nazia Syed

R

R. Goel

A

A. Khan

S

Sartaj Ahmad

G

Gourav Dey

K

K. Mudgal

A

Aditi Chatterjee

T

Tai‐Chung Huang

J

J. Zhong

X

Xinyan Wu

P

Patrick G. Shaw

D

Donald Freed

M

M. S. Zahari

K

K. Mukherjee

S

S. Shankar

A

A. Mahadevan

H

Henry H. N. Lam

C

Christopher J. Mitchell

S

S. Shankar

P

P. Satishchandra

J

J. Schroeder

R

R. Sirdeshmukh

A

A. Maitra

S

S. Leach

C

C. Drake

M

M. Halushka

T

T. Prasad

R

R. Hruban

C

C. Kerr

G

Gary D Bader

C

C. Iacobuzio-Donahue

H

H. Gowda

A

A. Pandey

Format Sitasi

APA MLA BibTeX
Kim, M., Pinto, S., Getnet, D., Nirujogi, R., Manda, S.S., Chaerkady, R. et al. (2014). A draft map of the human proteome. https://doi.org/10.1038/nature13302

Akses Cepat

Lihat di Sumber doi.org/10.1038/nature13302
Informasi Jurnal
Tahun Terbit
2014
Bahasa
en
Total Sitasi
2134×
Sumber Database
Semantic Scholar
DOI
10.1038/nature13302
Akses
Open Access ✓