Semantic Scholar Open Access 2018 321 sitasi

Escherichia coli as a host for metabolic engineering.

Sammy Pontrelli T. Chiu Ethan I. Lan Frederic Y.-H. Chen Peiching Chang +1 lainnya

Lihat Sumber DOI

Abstrak

Over the past century, Escherichia coli has become one of the best studied organisms on earth. Features such as genetic tractability, favorable growth conditions, well characterized biochemistry and physiology, and availability of versatile genetic manipulation tools make E. coli an ideal platform host for development of industrially viable productions. In this review, we discuss the physiological attributes of E. coli that are most relevant for metabolic engineering, as well as emerging techniques that enable efficient phenotype construction. Further, we summarize the large number of native and non-native products that have been synthesized by E. coli, and address some of the future challenges in broadening substrate range and fighting phage infection.

Topik & Kata Kunci

Medicine Biology

Penulis (6)

Sammy Pontrelli

T. Chiu

Ethan I. Lan

Frederic Y.-H. Chen

Peiching Chang

J. Liao

Format Sitasi

APA MLA BibTeX

Pontrelli, S., Chiu, T., Lan, E.I., Chen, F.Y., Chang, P., Liao, J. (2018). Escherichia coli as a host for metabolic engineering.. https://doi.org/10.1016/j.ymben.2018.04.008

Akses Cepat

Lihat di Sumber doi.org/10.1016/j.ymben.2018.04.008

Informasi Jurnal

Tahun Terbit: 2018
Bahasa: en
Total Sitasi: 321×
Sumber Database: Semantic Scholar
DOI: 10.1016/j.ymben.2018.04.008
Akses: Open Access ✓