Redox Biochemistry of Hydrogen Sulfide*
Abstrak
H2S, the most recently discovered gasotransmitter, might in fact be the evolutionary matriarch of this family, being both ancient and highly reduced. Disruption of γ-cystathionase in mice leads to cardiovascular dysfunction and marked hypertension, suggesting a key role for this enzyme in H2S production in the vasculature. However, patients with inherited deficiency in γ-cystathionase apparently do not present vascular pathology. A mitochondrial pathway disposes sulfide and couples it to oxidative phosphorylation while also exposing cytochrome c oxidase to this metabolic poison. This report focuses on the biochemistry of H2S biogenesis and clearance, on the molecular mechanisms of its action, and on its varied biological effects.
Penulis (2)
O. Kabil
R. Banerjee
Akses Cepat
- Tahun Terbit
- 2010
- Bahasa
- en
- Total Sitasi
- 695×
- Sumber Database
- Semantic Scholar
- DOI
- 10.1074/jbc.R110.128363
- Akses
- Open Access ✓