Semantic Scholar Open Access 2021 14 sitasi

The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

S. Uyttebroek J. Onsea W. Metsemakers L. Dupont D. Devolder +4 lainnya

Lihat Sumber DOI

Abstrak

Chronic rhinosinusitis is a common condition affecting 5–12% of the general population worldwide. In a limited number of cases, the disease is recalcitrant to medical and surgical interventions, causing a major impact on physical, social and emotional well-being and increasing pressure on healthcare systems. Biofilm formation and dysbiosis caused by Staphylococcus aureus and Pseudomonas aeruginosa play a role in the pathogenesis of recalcitrant chronic rhinosinusitis. In these cases, a promising treatment alternative is the application of bacteriophages, which are viruses that infect and lyse bacteria. In this review, we appraise the evidence for the use of bacteriophages in the treatment of recalcitrant chronic rhinosinusitis. Additionally, (dis)advantages of bacteriophages and considerations for implementation of phage therapy in otorhinolaryngology practice will be discussed.

Topik & Kata Kunci

Medicine

Penulis (9)

S. Uyttebroek

J. Onsea

W. Metsemakers

L. Dupont

D. Devolder

J. Wagemans

R. Lavigne

I. Spriet

L. Van Gerven

Format Sitasi

APA MLA BibTeX

Uyttebroek, S., Onsea, J., Metsemakers, W., Dupont, L., Devolder, D., Wagemans, J. et al. (2021). The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis. https://doi.org/10.3390/antibiotics10060675

Akses Cepat

Lihat di Sumber doi.org/10.3390/antibiotics10060675

Informasi Jurnal

Tahun Terbit: 2021
Bahasa: en
Total Sitasi: 14×
Sumber Database: Semantic Scholar
DOI: 10.3390/antibiotics10060675
Akses: Open Access ✓